Providing the evidence for evidence-based medicine©
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2021 Annual Report - 31st Anniversary
The OUTCOMES RESEARCH Group was formed in 1990 at the University of California in San Francisco and subsequently became an institute when the group's administrative center moved to the University of Louisville in March of 2000. In 2005, OUTCOMES RESEARCH became a department at the Cleveland Clinic. After 15 years, the Department of OUTCOMES RESEARCH now includes 65 members at the Clinic, among about 190 academic investigators in twenty countries including the Austria, Canada, China, Ireland, Israel, Japan, China, and the United States. The Consortium is non-profit; its only goal is thus participation in high-quality research.
The Consortium has published more than 1,600 full papers and more than 80 editorials. The collaboration publishes a full paper every 3 days.
The Consortium is currently involved in about 150 clinical studies, including many large multi-center outcome trials. Funding for the Consortium’s funding is from various peer-reviewed granting agencies, and we also collaborate with companies that make innovative devices and drugs, often conducting major trials that lead to regulatory certification. The Consortium facilitates scientific exchange and collaboration necessary for technically complex outcomes studies involving hundreds or thousands of patients. Additional information is available at www.OR.org.
Aspirations
Outcomes research seeks to understand the end results of particular health care practices and interventions. End results include effects that people experience and care about, such as change in the ability to function. In particular, for individuals with chronic conditions—where cure is not always possible—end results include quality of life as well as mortality. By linking the care people get to the outcomes they experience, outcomes research has become the key to developing better ways to monitor and improve the quality of care.
The general goal of the OUTCOMES RESEARCH Consortium is to evaluate inexpensive, low-risk interventions that are easy to implement yet likely to markedly improve outcome. For example, we have shown that simply maintaining intraoperative normothermia markedly reduces the risk of complications — and does so at trivial cost. A consequence of our work is that active intraoperative warming has become routine, whereas it was previously rare. Current focus areas include cardiovascular complications, postoperative delirium, and management of acute surgical pain.
Mission
Be the world’s leading clinical anesthesia research organization.
Behaviors
1. Publish more high-impact, peer-reviewed clinical research papers (quantified as number times impact) than any other anesthesia organization.
2. Recruit more extra-mural clinical research funding than any other anesthesia organization, with “clinical research” being defined as research conducted with human subjects.
3. Train clinical investigators at all levels.
Personnel
Administrative Structure
 |  |
| Director, Daniel I. Sessler MD, Cleveland | Vice-director: Alparslan Turan MD. Cleveland |
2021 Site Directors
Donal Buggy Dublin Ireland
Peter Szmuk Dallas USA
Yuguang Huang, Dong-Xin Wang Beijing China
Thomas Volk Homburg Germany
Colin Royse Melbourne Australia
Brian Ilfeld San Diego USA
PJ Devereaux Hamilton Canada
Barak Cohen Tel Aviv Israel
Ngai Liu Paris France
Bernd Saugel Hamburg Germany
General Members
| Member | City | Country |
|---|---|---|
| Alaa A. Abd-Elsayed, M.D. | Madison | USA |
| Basem B. Abdelmalak, M.D. | Cleveland | USA |
| Janet Adegboye, M.D. | Baltimore | USA |
| Sanchit Ahuja, M.D. | Detroit | USA |
| Wael Ali Sakr Esa, M.D. | Cleveland | USA |
| Federico Almonacid, MD | Cleveland | USA |
| Jorge Andres Araujo Duran, M.D. | Cleveland | USA |
| Harendra Arora, M.D. | Chapel Hill | USA |
| Valentina Assenzo, M.D. | Suresnes, Paris | France |
| Abdulkadir Atim, M.D. | Ankara | Turkey |
| Sabry Ayad, M.D. | Cleveland | USA |
| Rovnat Babazade, M.D. | Galveston | USA |
| Gausan Bajracharya, M.D. | Cleveland | USA |
| Omer Bakal, M.D. | Cleveland | USA |
| Karsten Bartels, MD, PhD, MBA | Omaha | USA |
| Allen Bashour, M.D. | Cleveland | USA |
| Beatrice Beck-Schimmer, MD | Zurich | Switzerland |
| Sergio D. Bergese, M.D. | Stony Brook | USA |
| Bruce M. Biccard, M.B.Ch.B., F.C.A., F.F.A.R.C.S.I., M.Med.Sc, Ph.D. | Cape Town | South Africa |
| Peter Biro, M.D. | Zurich | Switzerland |
| Joshua A. Bloomstone, M.D., M.Sc | Glendale | USA |
| Hagen Bomberg, M.D. | Zurich | Switzerland |
| Mauro Bravo, M.D. | Cleveland | USA |
| Jack Brooker, MD | Cleveland | USA |
| Donal J. Buggy, M.D., FRCPI, FRCACSI, FRCA | Dublin | Ireland |
| Juan Cata, M.D. | Houston | USA |
| Praveen Chahar, M.D., F.C.A.R.C.S.I. | Cleveland | USA |
| Athanasios F. Chalkias, MD, MSc, PhD, FESC, FAcadTM, FCP | Larisa | Greece |
| Surendrasingh S. Chhabada, M.D. | Cleveland | USA |
| Anne Cipriani | Cleveland | USA |
| Barak Cohen, M.D. | Tel Aviv | Israel |
| Allen Collins | Cleveland | USA |
| Jacek B. Cywinski, M.D. | Cleveland | USA |
| Albert Dahan, MD | Leiden | Netherlands |
| Jarrod E. Dalton, Ph.D. | Cleveland | USA |
| Gildasio S. De Oliveira Jr., M.D., M.S.C.I. | Providence | USA |
| Jagan Devarajan, MD | Cleveland | USA |
| Philip J. Devereaux, M.D., Ph.D. | Hamilton | Canada |
| Aimee Drury | Cleveland | USA |
| Lei Du, M.D. | Chengdu | China |
| Emmanuelle Duceppe, MD., Ph.D. | Montreal | Canada |
| Andra E. Duncan, M.D. | Cleveland | USA |
| Ruthy Edry, M.D. | Haifa | Israel |
| Proshad N. Efune, M.D. | Dallas | USA |
| Elyad Ekrami, MD | Cleveland | USA |
| Hesham Elsharkawy, M.D. | Cleveland | USA |
| Okan Ermis, M.D. | Cleveland | USA |
| Hani Essber, M.D. | Cleveland | USA |
| Stephanie Ezeoke, BS | Cleveland | USA |
| Tibi Ezri, M.D. | Tel Aviv | Israel |
| Ehab S.A. Farag, M.D., F.R.C.A. | Cleveland | USA |
| Tobias Fink, M.D. | Homburg | Germany |
| John J. Finneran IV, M.D. | San Diego | USA |
| Edith Fleischmann, M.D. | Vienna | Austria |
| Bela Fulesdi, M.D., Ph.D. | Debrecen | Hungary |
| Rodney A. Gabriel, M.D. | La Jolla | USA |
| Marcelo Gama de Abreu, M.D., M.Sc., Ph.D., D.E.S.A | Cleveland | USA |
| Martin V. Grady, M.D. | Mayfield Heights | USA |
| Yanyan Han, MS | Cleveland | USA |
| Manal Hassan, M.D. | Mayfield Heights | USA |
| Yuguang Huang, M.D. | Beijing | China |
| Tobias Hüppe, M.D., D.E.S.A., E.D.I.C. | Homburg (Saar) | Germany |
| Takehiko Ikeda, M.D. | Tokorozawa | Japan |
| Brian M. Ilfeld, M.D., M.S. | San Diego | USA |
| Ilker Ince, MD | Erzurum | Turkey |
| Steven R. Insler, D.O. | Cleveland | USA |
| Daniela C. Ionescu, Ph.D., D.E.A.A. | Cluj-Napoca | Romania |
| Tadahiko Ishiyama, M.D., Ph.D. | Chuo | Japan |
| Pia Jaeger, M.D., Ph.D. | Copenhagen | Denmark |
| Jens-Ulrik S. Jensen, M.D., Ph.D. | Copenhagen | Denmark |
| Qiliang Jiang, M.D., Ph.D. | Shanghai | China |
| Roberta Johnson | Cleveland | USA |
| Barbara Kabon, M.D. | Vienna | Austria |
| Tyler Karras, DO | Cleveland | USA |
| Roop Kaw, M.D. | Cleveland | USA |
| Ashish K. Khanna, M.D., F.C.C.P., F.C.C.M. | Wake Forest | USA |
| Sandeep Khanna, M.D. | Cleveland | USA |
| Daniel Kim, M.D. | Houston | USA |
| Oliver Kimberger, M.D. | Vienna | Austria |
| Ryu Komatsu, M.D. | Baltimore | USA |
| Orkun Kopac, MD | Cleveland | USA |
| Sascha Kreuer, M.D. | Homburg | Germany |
| Priya A. Kumar, M.D. | Chapel Hill | USA |
| Andrea M. Kurz, M.D. | Cleveland | USA |
| Esra Kutlu Yalcin, M.D. | Cleveland | USA |
| Giovanni Landoni, M.D. | Milan | Italy |
| Kai Li, M.D., Ph.D. | Cleveland | USA |
| Qian Li, M.D. | Chengdu | China |
| Jing Lin, M.D. | Chengdu | China |
| Liu Liu, M.A. | Cleveland | USA |
| Ngai Liu, M.D., Ph.D. | Suresnes | France |
| Vladimir V. Lomivorotov, M.D., Ph.D. | Novosibirsk | Russia |
| Dominik Lorenz, M.D. | Homburg / Saar | Germany |
| Anthony T. Machi, M.D. | Dallas | USA |
| Kamal Maheshwari, M.D., M.P.H. | Cleveland | USA |
| Guangmei Mao, M.S. | Cleveland | USA |
| Metty Markwei, B.S. | Baltimore | USA |
| Edward J. Mascha, Ph.D. | Cleveland | USA |
| Takashi Matsukawa, M.D. | Chuo | Japan |
| Felix Maurer, B.S. | Homburg | Germany |
| Mark Mettler | Cleveland | USA |
| Scott A. Miller, M.D. | Winston Salem | USA |
| Steven C. Minear, MD | Weston | USA |
| Toshiki Mizobe, M.D., Ph.D. | Kyoto | Japan |
| Mateo Montalvo, M.D. | Cleveland | USA |
| Eassen Mu, M.D. | Beijing | China |
| Carolin Müller, M.D. | Homburg | Germany |
| Lukas M. Müller-Wirtz, M.D. | Homburg | Germany |
| Yasuko Nagasaka, M.D., Ph.D. | Tokyo | Japan |
| Yasufumi Nakajima, M.D., Ph.D. | Hirakata | Japan |
| Rod Nault, M.S. | Cleveland | USA |
| Tyng Yan Ng, M.B.B.S. | Kuala Lumpur | Malaysia |
| Ben O’Brien, M.D., Ph.D., M.H.B.A., F.R.C.A., F.F.I.C.M. | Berlin | Germany |
| Beth O’Brien, B.S. | Cleveland | USA |
| Detlef E.R. Obal, M.D., Ph.D., D.E.S.A. | Palo Alto | USA |
| Ibrahim Onal, M.D. | Konya | Turkey |
| Makoto Ozaki, M.D., Ph.D. | Tokyo | Japan |
| Matt A. Pappas, M.D., M.P.H. | Cleveland | USA |
| Marie-Odile Parat, Pharm.D., Ph.D. | Woolloongabba | Australia |
| Lijian Pei, M.D. | Beijing | China |
| Silvia E. Perez-Protto, M.D., M.S. | Cleveland | USA |
| Olga M. Plattner, M.D. | Vienna | Austria |
| Attila Podolyak, M.D. | Cleveland | USA |
| Xuan Pu, M.S. | Cleveland | USA |
| Yuwei Qiu, M.D. | Shanghai | China |
| Shobana Rajan, M.D. | Cleveland | USA |
| Christian Reiterer, MD | Vienna | Austria |
| David A. Rincon-Valenzuela, M.D., M.Sc. | Bogot√° | Colombia |
| Eva Rivas Ferreira, M.D. | Barcelona | Spain |
| Efrain Riveros-Perez, M.D. | Augusta | USA |
| Fabio A. Rodriguez-Patarroyo, M.D. | Cleveland | USA |
| Reitze N. Rodseth, M.B.Ch.B., F.C.A., M.Med. | Durban | South Africa |
| Julian V. Rossler, M.D. | Zurich | Switzerland |
| Colin Royse, M.D. | Melbourne | Australia |
| Kurt Ruetzler, M.D. | Cleveland | USA |
| Remie Saab, M.D. | Cleveland | USA |
| Leif Saager, M.D. | Goettinghen | Germany |
| Wael Saasouh, M.D. | Detroit | USA |
| Ogena Saied | Cleveland | USA |
| Vafi Salmasi, M.D. | Palo Alto | USA |
| Ethan L. Sanford, M.D. | Dallas | USA |
| Bernd Saugel, M.D. E.D.I.C. | Hamburg | Germany |
| Rita Saynhalath, M.D. | Dallas | USA |
| Yehoshua-Nadav Schacham, M.D. | Ramat-Gan | Israel |
| Eitan Scher Nemirovsky, MD | Cleveland | USA |
| Martin Schlapfer, M.D., M.Sc. | Zurich | Switzerland |
| Marc Schmidt, M.D. | Zurich | Switzerland |
| Gokhan Sertcakacilar, MD | Cleveland | USA |
| Daniel I. Sessler, M.D. | Cleveland | USA |
| Karan Shaw, M.S. | Cleveland | USA |
| Tetsuya Shimada, M.D. | Tokorozawa | Japan |
| Alexis Skolaris | Cleveland | USA |
| Jeff W. Steiner, D.O. | Dallas | USA |
| Matthew W. Swisher, M.D., M.S. | La Jolla | USA |
| Wojciech Szczeklik, M.D., Ph.D. | Krakow | Poland |
| Peter Szmuk, M.D. | Dallas | USA |
| Abdullah S. Terkawi, M.D. | Charlottesville | USA |
| Yasin Tire, MD | Cleveland | USA |
| Uchida Tokujiro, M.D., Ph.D. | Tokyo | Japan |
| David Torres, M.D. | Santiago | Chile |
| Alparslan Turan, M.D. | Cleveland | USA |
| Tamas Vegh, M.D., Ph.D. | Debrecen | Hungary |
| Andrew Volio, D.O. | Cleveland | USA |
| Thomas Volk, M.D. | Homburg | Germany |
| Anupama Wadhwa, M.D. | San Diego | USA |
| Michael Walters | Cleveland | USA |
| Catherine I. Wang, M.D. | Beijing | China |
| Dong Wang, M.S. | Cleveland | USA |
| Dong-Xin Wang, M.D., Ph.D. | Beijing | China |
| Jiayi Wang, MD | Shanghai | China |
| Peiyan Wang, MS | Cleveland | USA |
| Marita Windpassinger, MD | Vienna | Austria |
| Kiran Winemiller, BS | Cleveland | USA |
| Jason Wu, M.D. | Shanghai | China |
| Lexie Xu, M.D. | Beijing | China |
| Ece Yamak Altinpulluk, M.D. | Istanbul | Turkey |
| Dongsheng Yang, M.S. | Cleveland | USA |
| Jean-Pierre Yared, M.D. | Cleveland | USA |
| Peter Yassa, MD | Cleveland | USA |
| Oguz Yilmaz, M.D. | Izmir | Turkey |
| Hai Yu, M.D. | Chengdu | China |
| Kan Zhang, M.D. | Cleveland | USA |
| Xiaobao Zhang, M.D. | Lianyungang | China |
Research Fellows
Chief Fellow: Esra Kutlu Yalcin, M.D. 2021-
| Name | Origin | Dates | Subsequent Position |
|---|---|---|---|
| Mauro Bravo, M.D. | Venezuela | 2018-21 | Anesthesia residency, Cleveland Clinic |
| Hani Essber, M.D. | Syria | 2019- | |
| Ece Yamak Altinpulluk, M.D. | Turkey | 2019-21 | Faculty, Cerrahpasa Medical School |
| Andrew Volio, D.O. | United States | 2019-21 | Internal medicine residency, Ohio State |
| Ahmed Algharrash, M.D. | Saudi Arabia | 2019-21 | Fellowship, McGill University |
| Omer Bakal, M.D. | Turkey | 2019- | |
| Kai Li, M.D. | China | 2019-21 | Anesthesia Faculty, Japan-China Union Hosp |
| Esra Kutlu Yalcin, M.D. | Turkey | 2019- | |
| Fabio Rodriguez Patarryo, M.D. | Colombia | 2019- | |
| Ahmed Al Gharrash, M.D. | Saudi Arabia | 2020-21 | Cardiac anesthesia fellowship, McGill Univ |
| Jorge Araujo Duran, M.D. | Colombia | 2020- | |
| Mateo Montalvo, M.D. | Ecuador | 2020- | |
| Sinem Sari Ozturk, M.D. | Turkey | 2020-21 | |
| Momina Sharif Umair, M.D. | Pakistan | 2020-21 | |
| Jeevan Shivakumar, M.D. | India | 2020-21 | |
| Marc Schmidt, M.D. | Switzerland | 2020-21 | Anesthesia faculty, University of Zurich |
| Tyler Karras, M.D. | USA | 2021-22 | Anesthesia residency, Alleghany Health |
| Eitan Scher, M.D. | Venezuela | 2021- | |
| Jack Booker, M.D. | Scotland | 2021- | |
| Federico A. Cardenas, M.D. | Colombia | 2021- | |
| Elyad Ekrami, M.D. | Iran | 2020- | |
| Orkun Kopac, M.D. | Turkey | 2021- | |
| Gokhan Sertcacilar, M.D. | Turkey | 2021- | |
| Yasin Tire, M.D. | Turkey | 2021- |
Graduate and Medical Students (full year)
| Name | Origin | Dates | Subsequent Position |
|---|---|---|---|
| Alexis Skolaris, B.S. | USA | 2019-21 | |
| David Lynn, B.S. | USA | 2020-20 | Coordinator, Taussig Cancer Center |
| David Hoying, B.S. | USA | 2020-21 | |
| Oguzalp Turan, M.S. | USA | 2020-21 | Northeast Ohio Medical School |
| Stephanie Ezeoke, B.S. | USA | 2021- | |
| Kiran Winemiller, B.S. | USA | 2021-22 | Case Western Dental School |
| Anne Cipraini, B.S. | USA | 2021-22 | Case Western Medical School |
| Nicole Brown, B.S. | USA | 2021- | |
| Metabel Markwei, B.S | USA | 2020-21 | Cleveland Clinic Lerner College of Medicine |
| Rod Nault, B.S. | USA | 2020-21 | Case Western Research School of Medicine |
Honors and Awards
| Name | Honor | Organization |
|---|---|---|
| Hesham Elsharkawy | Associate Editor | Reg Anesth Pain Management |
| Ashish Khanna | Vice-chair for research | Wake Forest, Department of Anesthesia |
| Sanchit Ahuja | Resident scholar | FAER |
| Juan Cata | Vice-chair for Clinical Research | Dept of Anesthesiology, MD Anderson |
| Jack Brooker | 2nd Place, resident research | Ohio Society of Anesthesia |
| Brian Ilfeld | Labat Award | American Society of Regional Anesthesia |
| Priya A. Kumar | Outstanding Service Award | UNC Anesthesiology |
| Athanasios Chalkias | Associate Editor | Frontiers in Medicine, Intensive Care & Anesthesiology |
Consortium Research Awards
The Gladys Sessler Prize is an endowed award that is given yearly. All members of the OUTCOMES RESEARCH Consortium are eligible. This year’s award was to Prof. Kamal Maheshwari.
The Best Fellow Award is given to the Department of OUTCOMES RESEARCH fellow who is voted by the faculty to have performed at the very highest level. This year’s award was given to Mauro Bravo who was Chief Fellow before starting anesthesia residency at the Cleveland Clinic.
Publications
Contribution to the world’s literature
An article by Pagel and Hudetz (BMC Anesthesiology 12:5, 2012) evaluated anesthesia publication trends. In 2010, the last year they report, there were 665 clinical research articles published in the most influential anesthesia journals: Anesthesiology, the British Journal of Anaesthesia, Anesthesia & Analgesia, Anaesthesia and the European Journal of Anaesthesia. The Consortium publishes about 40 papers per year in the 14 journals they considered. The OUTCOMES RESEARCH Consortium thus publishes more than at least 4% of the clinical research in high-profile general anesthesia journals. Of note, the Consortium also publishes nearly as many papers in specialty journals ranging from pain to critical care to neuroscience, and in major multi-specialty journals. Overall, the Consortium publishes a full paper every 2.5 days.
Since inception, the Consortium has published more than 1,600 full papers and more than 80 editorials.
Links to PDF versions of most full papers.
Featured on journal covers this year
This year’s featured papers
Du YT, Li YW, Zhao BJ, Guo XY, Feng Y, Zuo MZ, Fu C, Zhou WJ, Li HJ, Liu YF, Cheng T, Mu DL, Zeng Y, Liu PF, Li Y, An HY, Zhu SN, Li XY, Li HJ, Wu YF, Wang DX, Sessler DI, Peking University Clinical Research Program Study Group: Long-term survival after combined epidural-general anesthesia or general anesthesia alone: Follow-up of a randomized trial. Anesthesiology 2021; 135: 233-45.
Background: Experimental and observational research suggests that combined epidural-general anesthesia may improve long-term survival after cancer surgery by reducing anesthetic and opioid consumption and by blunting surgery-related inflammation. This study therefore tested the primary hypothesis that combined epidural-general anesthesia improves long-term survival in elderly patients.
Methods: This article presents a long-term follow-up of patients enrolled in a previous trial conducted at five hospitals. Patients aged 60 to 90 yr and scheduled for major noncardiac thoracic and abdominal surgeries were randomly assigned to either combined epidural-general anesthesia with postoperative epidural analgesia or general anesthesia alone with postoperative intravenous analgesia. The primary outcome was overall postoperative survival. Secondary outcomes included cancer-specific, recurrence-free, and event-free survival.
Results: Among 1,802 patients who were enrolled and randomized in the underlying trial, 1,712 were included in the long-term analysis; 92% had surgery for cancer. The median follow-up duration was 66 months (interquartile range, 61 to 80). Among patients assigned to combined epidural-general anesthesia, 355 of 853 (42%) died compared with 326 of 859 (38%) deaths in patients assigned to general anesthesia alone: adjusted hazard ratio, 1.07; 95% CI, 0.92 to 1.24; P = 0.408. Cancer-specific survival was similar with combined epidural-general anesthesia (327 of 853 [38%]) and general anesthesia alone (292 of 859 [34%]): adjusted hazard ratio, 1.09; 95% CI, 0.93 to 1.28; P = 0.290. Recurrence-free survival was 401 of 853 [47%] for patients who had combined epidural-general anesthesia versus 389 of 859 [45%] with general anesthesia alone: adjusted hazard ratio, 0.97; 95% CI, 0.84 to 1.12; P = 0.692. Event-free survival was 466 of 853 [55%] in patients who had combined epidural-general anesthesia versus 450 of 859 [52%] for general anesthesia alone: adjusted hazard ratio, 0.99; 95% CI, 0.86 to 1.12; P = 0.815.
Conclusions: In elderly patients having major thoracic and abdominal surgery, combined epidural-general anesthesia with epidural analgesia did not improve overall or cancer-specific long-term mortality. Nor did epidural analgesia improve recurrence-free survival. Either approach can therefore reasonably be selected based on patient and clinician preference.
Published Full Papers and editorials
Abdelmalak BB, Doyle DJ: Updates and controversies in anesthesia for advanced interventional pulmonology procedures. Curr Opin Anaesthesiol 2021; 34: 455-63
2. Aghamelu O, Buggy P, Smith G, Inzitari R, Wall T, Buggy DJ: Serum NETosis expression and recurrence risk after regional or volatile anaesthesia during breast cancer surgery: A pilot, prospective, randomised single-blind clinical trial. Acta Anaesthesiol Scand 2021; 65: 313-9
3. Arora H, Kumar PA: Case Series of Vacuum-Assisted Thrombectomy: An Acceptable Trade-Off in Evidence-Based Methodology? J Cardiothorac Vasc Anesth 2021; 35: 1046-8
4. Bhatia M, Kumar PA: Pro: Venoarterial ECMO Should Be Considered in Patients With COVID-19. J Cardiothorac Vasc Anesth 2021; 35: 703-6
5. Bhatia M, Kumar PA: Con: Routine Use of Fresh Frozen Plasma Should Not Be Used to Prime Cardiopulmonary Bypass Circuits During Cardiac Surgery. J Cardiothorac Vasc Anesth 2021; 35: 3122-4
6. Bravo M, Bakal O, Rivas E, Mascha EJ, Pu X, Mosteller L, Rodriguez-Patarroyo F, Essber H, AlGharrash A, Turan A: Effect of intravenous acetaminophen on mean arterial blood pressure: A post hoc analysis of the effect of intravenous acetaminophen on postoperative hypoxemia after abdominal surgery trial. Anesth Analg 2021; 133: 1532-9
7. Buggy DJ, Nolan R, Coburn M, Columb M, Hermanides J, Hollman MW, Zarbock A: Protocol for a prospective, international cohort study on the Management and Outcomes of Perioperative Care among European Diabetic Patients (MOPED). BMJ Open 2021; 11: e044394
8. Chalkias A, Mongardon N, Boboshko V, Cerny V, Constant AL, De Roux Q, Finco G, Fumagalli F, Gkamprela E, Legriel S, Lomivorotov V, Magliocca A, Makaronis P, Mamais I, Mani I, Mavridis T, Mura P, Ristagno G, Sardo S, Papagiannakis N, Xanthos T, Consortium P: Clinical practice recommendations on the management of perioperative cardiac arrest: A report from the PERIOPCA Consortium. Crit Care 2021; 25: 265
9. Chalkias A, Pantazopoulos I, Papagiannakis N, Skoulakis A, Laou E, Kolonia K, Ntalarizou N, Tourlakopoulos K, Pagonis A, Kampolis C, De Guadiana Romualdo LG, Ragias D, Eugen-Olsen J, Gourgoulianis K, Arnaoutoglou E, Investigators S: Sinus bradycardia is associated with poor outcome in critically ill patients with COVID-19 due to the B.1.1.7 Lineage. Toxicol Rep 2021; 8: 1394-8
10. Chen X, Owen CA, Huang EC, Maggard BD, Latif RK, Clifford SP, Li J, Huang J: Artificial intelligence in echocardiography for anesthesiologists. J Cardiothorac Vasc Anesth 2021; 35: 251-61
11. Chin KJ, Versyck B, Elsharkawy H, Rojas Gomez MF, Sala-Blanch X, Reina MA: Anatomical basis of fascial plane blocks. Reg Anesth Pain Med 2021; 46: 581-99
12. Chow JH, Khanna AK, Kethireddy S, Yamane D, Levine A, Jackson AM, McCurdy MT, Tabatabai A, Kumar G, Park P, Benjenk I, Menaker J, Ahmed N, Glidewell E, Presutto E, Cain S, Haridasa N, Field W, Fowler JG, Trinh D, Johnson KN, Kaur A, Lee A, Sebastian K, Ulrich A, Pena S, Carpenter R, Sudhakar S, Uppal P, Fedeles BT, Sachs A, Dahbour L, Teeter W, Tanaka K, Galvagno SM, Herr DL, Scalea TM, Mazzeffi MA: Aspirin use is associated with decreased mechanical ventilation, intensive care unit admission, and in-hospital mortality in hospitalized patients with coronavirus disease 2019. Anesth Analg 2021; 132: 930-41
13. Chow JH, Wittwer ED, Wieruszewski PM, Khanna AK: Evaluating the evidence for angiotensin II for the treatment of vasoplegia in critically ill cardiothoracic surgery patients. J Thorac Cardiovasc Surg 2021
14. Christensen AL, Jacobs E, Maheshwari K, Xing F, Zhao X, Simon SE, Domino KB, Posner KL, Stewart AF, Sanford JA, Sessler DI: Development and evaluation of a risk-adjusted measure of intraoperative hypotension in patients having nonemergent, noncardiac surgery. Anesth Analg 2021; 133: 445-54
15. Cohen B, Rivas E, Pu X, Maheshwari K, Araujo-Duran JA, Turan O, Volio A, Yalcin EK, Turan A: Diurnal blood pressure variation in adults after abdominal surgery-An observational cohort study. J Clin Anesth 2021; 77: 110633
16. Cutler NS, Rasmussen BM, Bredeck JF, Lata AL, Khanna AK: Angiotensin II for critically ill patients with shock after heart transplant. J Cardiothorac Vasc Anesth 2021; 35: 2756-62
17. Douin DJ, Krause M, Williams C, Tanabe K, Fernandez-Bustamante A, Quaye AN, Ginde AA, Bartels K: Corticosteroid administration and impaired glycemic control in mechanically ventilated covid-19 patients. Semin Cardiothorac Vasc Anesth 2021: 10892532211043313
18. Du YT, Li YW, Zhao BJ, Guo XY, Feng Y, Zuo MZ, Fu C, Zhou WJ, Li HJ, Liu YF, Cheng T, Mu DL, Zeng Y, Liu PF, Li Y, An HY, Zhu SN, Li XY, Li HJ, Wu YF, Wang DX, Sessler DI, Peking University Clinical Research Program Study Group: Long-term survival after combined epidural-general anesthesia or general anesthesia alone: Follow-up of a randomized trial. Anesthesiology 2021; 135: 233-45
19. Duarte P, Riveros-Perez E: Understanding the cycles of COVID-19 incidence: Principal Component Analysis and interaction of biological and socio-economic factors. Annals of Medicine and Surgery 2021; 66
20. Efrimescu CI, Buggy PM, Buggy DJ: Neutrophil Extracellular Trapping Role in Cancer, Metastases, and Cancer-Related Thrombosis: a Narrative Review of the Current Evidence Base. Curr Oncol Rep 2021; 23: 118
21. Elsharkawy H: The external oblique intercostal block: Anatomic evaluation and case series. Pain Medicine 2021; 22: 2436-42
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116. Shopova T, Huppe T, Wolf B, Sessler DI, Volk T, Groesdonk HV, Kreuer S, Maurer F: Quantitative determination of fosfomycin in 10 mul of plasma and dialysate by hydrophilic interaction liquid chromatography electrospray ionization mass spectrometry. J Chromatogr Sci 2021; 59: 165-74
117. Siddiqui S, Bartels K, Schaefer MS, Novack L, Sreedharan R, Ben-Jacob TK, Khanna AK, Nunnally ME, Souter M, Simmons ST, Williams G: Critical care medicine practice: A pilot survey of us anesthesia critical care medicine-trained physicians. Anesth Analg 2021; 132: 761-9
118. Smeltz AM, Kumar PA: Con: Qualitative left ventricular ejection fraction is not sufficient for patients undergoing cardiac surgery. J Cardiothorac Vasc Anesth 2021; 35: 335-8
119. Smeltz AM, Kumar PA: Pro: General Anesthesia Is Superior to Regional Anesthesia for Patients with Pulmonary Hypertension Undergoing Noncardiac Surgery. J Cardiothorac Vasc Anesth 2021; 35: 1884-7
120. Smeltz AM, Kumar PA: An Unusual Left Ventricular Outflow Tract Obstruction, or Just Another Artifact? J Cardiothorac Vasc Anesth 2021; 35: 1541-3
121. Smeltz AM, Kumar PA, Arora H: Anesthesia for Combined Heart and Liver Transplantation. J Cardiothorac Vasc Anesth 2021; 35: 3350-61
122. Smischney NJ, Khanna AK, Brauer E, Morrow LE, Ofoma UR, Kaufman DA, Sen A, Venkata C, Morris P, Bansal V: Risk factors for and outcomes associated with peri-intubation hypoxemia: A multicenter prospective cohort study. J Intensive Care Med 2021; 36: 1466-74
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124. Stapelfeldt WH, Khanna AK, Shaw AD, Shenoy AV, Hwang S, Stevens M, Smischney NJ: Association of perioperative hypotension with subsequent greater healthcare resource utilization. J Clin Anesth 2021; 75: 110516
125. Subramanian V, Mascha EJ, Kattan MW: Developing a clinical prediction score: Comparing prediction accuracy of integer scores to statistical regression models. Anesth Analg 2021; 132: 1603-13
126. Sulyok I, Camponovo C, Zotti O, Haslik W, Kostenberger M, Likar R, Leuratti C, Donati E, Kimberger O: A randomised, non-inferiority study of chloroprocaine 2% and ropivacaine 0.75% in ultrasound-guided axillary block. Sci Rep 2021; 11: 10035
127. Sun C, Gao H, Zhang Y, Pei L, Huang Y: Risk stratification for organ/space surgical site infection in advanced digestive system cancer. Frontiers in Oncology 2021; 11: 705335
128. Szarpak L, Filipiak KJ, Mosteller L, Jaguszewski M, Smereka J, Ruetzler K, Ahuja S, Ladny JR: Survival, neurological and safety outcomes after out of hospital cardiac arrests treated by using prehospital therapeutic hypothermia: A systematic review and meta-analysis. Am J Emerg Med 2021; 42: 168-77
129. Tire Y, Yazar MA, Erdem SS: Can changes in platelet count, mean platelet volume, and platelet distribution width be used to determine the severity of COVID-19? Medical Science and Discovery 2021; 8: 581-5
130. Tripathi S, Sayed IA, Dapul H, McGarvey JS, Bandy JA, Boman K, Kumar VK, Bansal V, Retford L, Cheruku S, Kaufman M, Heavner SF, Danesh VC, St Hill CA, Khanna AK, Bhalala U, Kashyap R, Gajic O, Walkey AJ, Gist KM: Risk factors for critical Coronavirus Disease 2019 and Mortality in Hospitalized Young Adults: An analysis of the Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS) Coronavirus Disease 2019 registry. Crit Care Explor 2021; 3: e0514
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132. Turan A, Cohen B, Elsharkawy H, Maheshwari K, Soliman LM, Babazade R, Ayad S, Hassan M, Elkassabany N, Essber HA, Kessler H, Mao G, Esa WAS, Sessler DI, Group ES: Transversus abdominis plane block with liposomal bupivacaine versus continuous epidural analgesia for major abdominal surgery: The EXPLANE randomized trial. J Clin Anesth 2021; 77: 110640
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135. Urman RD, Khanna AK, Bergese SD, Buhre W, Wittmann M, Le Guen M, Overdyk FJ, Di Piazza F, Saager L: Postoperative opioid administration characteristics associated with opioid-induced respiratory depression: Results from the PRODIGY trial. J Clin Anesth 2021; 70: 110167
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Published editorials
1. Ahuja S, Luedi MM: Too little or too much anesthesia: Age paradox of electroencephalogram indices (editorial). J Clin Anesth 2021; 73: 110358
2. Bartels K, Lobato RL, Bradley CJ: Risk scores to improve quality and realize health economic gains in perioperative care (editorial). Anesth Analg 2021; 133: 606-9
3. Buggy DJ, Riedel B, Sessler DI: Can anaesthetic technique influence cancer outcome? The next steps (editorial). Br J Anaesth 2021; 127: 5-7
4. Flick M, Kouz K, Chew MS, Saugel B: Haemodynamic monitoring in circulatory shock - in a nutshell (editorial). Anaesth Crit Care Pain Med 2021; 41: 101003
5. Flick M, Saugel B: The surgical patient (editorial). Curr Opin Crit Care 2021; 27: 668-9
6. Goeller JK, Bartels K: Improving prediction to prevent perioperative morbidity (editorial). Br J Anaesth 2021; 127: 671-4
7. Khanna AK, Gan TJ: Myocardial injury after noncardiac surgery-slightly heavier may be better (editorial). Anesth Analg 2021; 132: 957-9
8. Khanna AK, Karamchandani K: Macrocirculation and microcirculation: The “Batman and Superman" story of critical care resuscitation (editorial). Anesth Analg 2021; 132: 280-3
9. Maheshwari K: Blood pressure stability: a road to better outcomes (editorial). J Clin Monit Comput 2021; 35: 679-80
10. Onal M, Onal O, Turan A: Can secondary lymphoid organs exert a favorable effect on the mild course of COVID-19 in children? (Editorial). Acta Otolaryngol 2021; 141: 83-4
11. Sessler DI: (Im)precise trial descriptions (editorial). Br J Anaesth 2021; 127: 824-5
12. Sessler DI, Short T: Intraoperative hypotension and complications (editorial). J Am Coll Cardiol 2021; 78: 1765-7
13. Sharma V, Sessler DI, Hausenloy DJ: The role of routine postoperative troponin measurement in the diagnosis and management of myocardial injury after non-cardiac surgery (editorial). Anaesthesia 2021; 76: 11-4
