2012 Annual Report
The OUTCOMES RESEARCH Group was formed in 1990 at the University of California in San Francisco and subsequently became an institute when the group's administrative center moved to the University of Louisville in March of 2000. In 2005, OUTCOMES RESEARCH became a department at the Cleveland Clinic. After 7 years, the Department of OUTCOMES RESEARCH now includes 52 members at the Clinic, among 126 academic investigators in fifteen countries including the Argentina, Austria, Belgium, Canada, China, Colombia, France, Germany, Hungary, Ireland, Israel, Italy, Japan, Romania, and the United States. The Consortium is non-profit; its only goal is thus participation in high-quality research.
The Consortium is currently involved in more than 100 clinical studies, including many large multi-center outcome trials. Much of the Consortium’s funding is from the National Institutes of Health, the Canadian Institutes of Health Research, and other peer-reviewed granting agencies. The Consortium facilitates scientific exchange and collaboration necessary for technically complex outcomes studies involving hundreds or thousands of patients. Additional information is available at www.OR.org.
Aspirations
OUTCOMES RESEARCH seeks to understand the end results of particular health care practices and interventions. End results include effects that people experience and care about, such as change in the ability to function. In particular, for individuals with chronic conditions—where cure is not always possible—end results include quality of life as well as mortality. By linking the care people get to the outcomes they experience, OUTCOMES RESEARCH has become the key to developing better ways to monitor and improve the quality of care.
The general goal of the OUTCOMES RESEARCH Consortium is to evaluate inexpensive, low-risk interventions that are easy to implement yet likely to markedly improve outcome. For example, we have shown that simply maintaining intraoperative normothermia markedly reduces the risk of complications — and does so at trivial cost. A consequence of our work is that active intraoperative warming has become routine, whereas it was rare a decade ago.
Mission
Be the world's leading anesthesia-related clinical research organization.
Behaviors
Publish more high-impact, peer-reviewed clinical research papers (quantified as number times impact) than any other anesthesia organization.
Recruit more extra-mural clinical research funding than any other anesthesia organization, with “clinical research” being defined as research conducted with human subjects.
Train clinical investigators at all levels.
Personnel
Administrative Structure
Director: Daniel I. Sessler, M.D. Cleveland USA
Associate Director: Andrea Kurz, M.D. Cleveland USA
Site Directors
Anupama Wadhwa, M.D. Louisville USA
Donal Buggy, M.D. Dublin Ireland
Marcel Chauvin, M.D. Paris France
Tibi Ezri, M.D. Tel Aviv Israel
Edith Fleischmann, M.D. Vienna Austria
Kate Leslie, M.D. Melbourne Australia
Makoto Ozaki, M.D. Tokyo Japan
Adrian O. Alvarez, M.D. Buenos Aires Argentina
Peter Szmuk, M.D. Dallas USA
General Members
| Member | City | Country |
|---|---|---|
| Alaa A. Abd-Elsayed, M.D. | Cincinnati | USA |
| Basem B. Abdelmalak, M.D. | Cleveland | USA |
| Awais Ahmed, M.D. | Cleveland | USA |
| Ozan Akça, M.D. | Louisville | USA |
| Zohaib Akhtar, M.D. | Cleveland | USA |
| Adrian O. Alvarez, M.D., Ph.D. | Buenos Aires | Argentina |
| Christian C. Apfel, M.D. | San Francisco | USA |
| Harendra Arora, M.D. | Chapel Hill | USA |
| Abdulkadir Atim, M.D. | Ankara | Turkey |
| Sabry Ayad, M.D. | Cleveland | USA |
| Allen Bashour, M.D. | Cleveland | USA |
| Maria Bauer, M.D. | New York | USA |
| Sergio D. Bergese, M.D. | Columbus | USA |
| Ethan Bernstein | Bethesda | USA |
| Catherine J. Binkley, D.D.S., Ph.D. | Louisville | USA |
| Mona Boaz, R.D., Ph.D. | Holon | Israel |
| Donal J. Buggy, M.D., FRCPI, FRCACSI, FRCA | Dublin | Ireland |
| Mohsin Buttar, M.D. | Cleveland | USA |
| Juan Cata, M.D. | Houston | USA |
| Nassib G. Chamoun, M.S. | Brookline | USA |
| Allen Collins | Cleveland | USA |
| Kenneth Cummings, III, M.D. | Cleveland | USA |
| Jacek B. Cywinski, M.D. | Cleveland | USA |
| Jarrod E. Dalton, M.A. | Cleveland | USA |
| Gildasio S. De Oliveira Jr., M.D. | Chicago | USA |
| Stacie G. Deiner, M.D. | New York | USA |
| Armin Deroee, M.D. | Cleveland | USA |
| Anthony G. Doufas, M.D., Ph.D. | Stanford | USA |
| Andra I. Duncan, M.D. | Cleveland | USA |
| Cameron Egan | Cleveland | USA |
| Hesham Elsharkawy, M.D. | Cleveland | USA |
| Stefan Engelen, M.D. | Antwerp | Belgium |
| Yashar Eshraghi, M.D. | Cleveland | USA |
| Shmuel Evron, M.D. | Holon | Israel |
| Tibi Ezri, M.D. | Holon | Israel |
| Ehab S.A. Farag, M.D., F.R.C.A. | Cleveland | USA |
| Mary Federico | Cleveland | USA |
| Marc A. Feldman, M.D., M.H.S. | Cleveland | USA |
| Edith Fleischmann, M.D. | Vienna | Austria |
| Alex Fu, B.S. | Cleveland | USA |
| Béla Fülesdi, M.D., Ph.D. | Debrecen | Hungary |
| Ignacia Gazmuri, M.D. | Cleveland | USA |
| Michael M.N. Ghobrial, M.D. | Cleveland | USA |
| Raktim Ghosh, M.D. | Cleveland | USA |
| Klesta K. Gjini, M.B.A. | Cleveland | USA |
| Martin V. Grady, M.D. | Mayfield Hts. | USA |
| J. Steve Hata, M.D., F.C.C.P., M.S.C. | Cleveland | USA |
| Brian Hesler, M.D. | Cleveland | USA |
| Christine E. Hillegas | Cleveland | USA |
| Hooman Honar, M.D. | Cleveland | USA |
| Ernst-Peter Horn, M.D. | Hamburg | Germany |
| Pedro F. Ibarra, M.D. | Bogota | Colombia |
| Brian M. Ilfeld, M.D., M.S. | San Diego | USA |
| Steven R. Insler, D.O. | Cleveland | USA |
| Daniela C. Ionescu, Ph.D., D.E.A.A. | Cluj-Napoca | Romania |
| Berta Johnson | Cleveland | USA |
| Barbara Kabon, M.D. | Vienna | Austria |
| Babak K. Kashy, M.D. | Cleveland | USA |
| Yusuke Kasuya, M.D. | Tokyo | Japan |
| Roop Kaw, M.D. | Cleveland | USA |
| Oliver Kimberger, M.D. | Vienna | Austria |
| Ryu Komatsu, M.D. | Cleveland | USA |
| Michael Kot, M.D. | Cleveland | USA |
| Priya A. Kumar, M.D. | Chapel Hill | USA |
| Andrea M. Kurz, M.D. | Cleveland | USA |
| Giovanni Landoni, M.D. | Milan | Italy |
| Wael Lasheen, M.D. | Cleveland | USA |
| Rainer Lenhardt, M.D. | Louisville | USA |
| Kate Leslie, M.D., F.A.N.Z.C.A. | Parkville | Australia |
| Jinbo Liu, M.D. | Cleveland | USA |
| Ngai Liu, M.D., Ph.D. | Suresnes | France |
| Ankit Maheshwari, M.D. | Cleveland | USA |
| Raihan Malik, M.D. | Cleveland | USA |
| Edward J. Mascha, Ph.D. | Cleveland | USA |
| Takashi Matsukawa, M.D. | Chuo | Japan |
| Rachel E. McKay, M.D. | San Francisco | USA |
| Gaby R. Mendoza, M.D. | Buenos Aires | Argentina |
| Maria Mendoza-Cuartas, M.D. | Cleveland | USA |
| Scott A. Miller, M.D. | Winston Salem | USA |
| Toshiki Mizobe, M.D., Ph.D. | Kyoto | Japan |
| Yasufumi Nakajima, M.D., Ph.D. | Kyoto | Japan |
| Edward M. Noguera, M.D. | Cleveland | USA |
| Detlef E.R. Obal, M.D., D.E.S.A. | Louisville | USA |
| Makoto Ozaki, M.D., Ph.D. | Tokyo | Japan |
| Krit Panjasawatwong, M.D. | Cleveland | USA |
| Marie-Odile Parat, Pharm.D., Ph.D. | Woolloongabba | Australia |
| Ivan Parra-Sanchez, M.D. | Cleveland | USA |
| Silvia E. Perez-Protto, M.D. | Cleveland | USA |
| Olga M. Plattner, M.D. | Vienna | Austria |
| Attila Podolyak, M.D. | Cleveland | USA |
| Radu B. Pop, M.S. | Dallas | USA |
| Stefan Rauch, M.D. | Louisville | USA |
| Luke Reynolds, M.Sc. | Halifax | Canada |
| David A. Rincón-Valenzuela, M.D., M.Sc. | Bogotá | Colombia |
| Reitze N. Rodseth, M.B.Ch.B., F.C.A. | Durban | South Africa |
| Kurt Ruetzler, M.D. | Vienna | Austria |
| Leif Saager, M.D. | Cleveland | USA |
| Vafi Salmasi, M.D. | Cleveland | USA |
| Sheryar Sarwar, M.D. | Cleveland | USA |
| Hiroaki Sato, M.D. | Yamanashi | Japan |
| Tamaki Sato, M.D. | Yamanashi | Japan |
| Thomas P. Schricker, M.D., Ph.D. | Montreal | Canada |
| Daniel I. Sessler, M.D. | Cleveland | USA |
| Aram Shahinyan, M.D. | Cleveland | USA |
| Ayako Shiba, M.D. | Minato-ku | Japan |
| Jeffrey H. Silverstein, M.D. | New York | USA |
| Tanya Smith, B.A. | Cleveland | USA |
| Thilak Sreenivasalu, M.D. | Cleveland | USA |
| Wolf Stapelfeldt, M.D. | Cleveland | USA |
| Jeff W. Steiner, D.O. | Dallas | USA |
| Zhuo Sun, M.D., Ph.D. | Cleveland | USA |
| Peter Szmuk, M.D. | Dallas | USA |
| Tanja A. Treschan, M.D. | Düsseldorf | Germany |
| Elena Trimbitas, B.B.A. | Cleveland | USA |
| Alparslan Turan, M.D. | Cleveland | USA |
| Belinda Udeh, Ph.D. | Cleveland | USA |
| Gretchen Upton, B.S. | Cleveland | USA |
| Tamás Végh, M.D. | Debrecen | Hungary |
| Anupama Wadhwa, M.D. | Louisville | USA |
| Jiang Wu, M.D. | Cleveland | USA |
| Dongsheng Yang, M.S. | Cleveland | USA |
| Jean-Pierre Yared, M.D. | Cleveland | USA |
| Jing You, M.S. | Cleveland | USA |
| Hani Yousef, M.D. | Cleveland | USA |
| Yosaf Zeyed, M.D. | Cleveland | USA |
| Yunxia Zuo, Ph.D., M.D. | Chengdu | China |
Research Fellows
| Name | Origin | Dates | Subsequent Position |
|---|---|---|---|
| Awais Ahmed, M.D. | Pakistan | 2011-12 | Internal Medicine Resident, Canton |
| Yashar Eshraghi, M.D. | Iran | 2011-12 | Anesthesia Resident, Metro General |
| Michael M. N. Ghobrial, M.D. | Egypt | 2011-12 | Internal Medicine, Fairview |
| Albatoul Bensitel, M.D. | Morocco | 2010-12 | Master’s program in clinical research |
| Abdulkadir Atim, M.D. | Turkey | 2010-12 | Faculty, Gulhane Military Medical |
| Sheryar Sarwar, M.D. | The Netherlands | 2010-12 | Internal Medicine Resident, Case |
| Crissy Irani, M.D. | India | 2010-11 | |
| Hooman Honar, M.D. | Canada | 2010- | |
| Ignatia Gazmuri Arrieta, M.D. | Chile | 2011- | |
| Zohaib Aktar, M.D. | Pakistan | 2012- | |
| Mohsin Buttar, M.D. | Pakistan | 2012- | |
| Raktim Ghosh, M.D. | India | 2012- | |
| Jinbo Liu, M.D. | China | 2012- | |
| Raihan Malik, M.D. | Pakistan | 2012- | |
| Zhuo Sun, M.D. | China | 2012- | |
| Krit Panjasawatwong, M.D. | Thailand | 2012- | |
| Brian Hesler, M.D. | United States | 2012- | |
| Hani Yousef, M.D. | Egypt | 2012- | |
| Yosef Zeyed, M.D. | Libya | 2012- | |
| Aram Shahinyan, M.D. | Albania | 2012- | |
| Wael Lasheen, M.D. | Egypt | 2012- | |
| Attila Podolyak, M.D. | Hungary | 2012- |
Graduate and Medical Students (full year)
| Name | Dates | Institution |
|---|---|---|
| Cameron Egan, B.S. | 2011-13 | University of Rochester |
| Alex Fu, B.S. | 2011-12 | Case Western Reserve University |
Medical Student and Resident Rotations
| Name | Dates | Institution |
|---|---|---|
| Brian Hesler, M.D. | 10/2011-07/2012 | Cleveland Clinic Anesthesia Residency |
| Aparna Dalal, M.D. | 03/2012 – 04/2012 | Cleveland Clinic Anesthesia Residency |
| Ankit Maheshwari, M.D. | 01/2012 – 12/2012 | Cleveland Clinic Anesthesia Residency |
| Francis Wong, M.D. | 08/2012 – 10/2012 | Cleveland Clinic Anesthesia Residency |
| Silvia Perez Protto, M.D. | 09/2012 – 03/2013 | Cleveland Clinic Anesthesia Residency |
Honors and Awards
| Name | Honor |
|---|---|
| Dongsheng Yang, M.S. | 1st Place, CCF Caregiver Celebrations Excellence Award |
| Yashar Eshraghi, M.D. | 3rd Place, MARC - DTT Study in Cardiovascular Studies |
| Brian Hesler, M.D. | 1st Place, Resident Research Day Oral Presentation |
| Michael Ghobrial, M.D. | $250 Travel Award 40th Annual SNACC Meeting |
| Alaa Abd-Elsayed, M.D. | 1st, 2nd, and 3rd place Ohio State Society of Anesthesia |
| Basem Abdelmalak, M.D. | Top 10 abstracts ASA Annual Meeting |
| Jinbo Liu, M.D. | Merlin Bumpus Award |
| Jinbo Liu, M.D. | 2nd Place Resident Research Day Oral Presentation |
Consortium Research Awards
The Gladys Sessler Prize is an endowed award that is given yearly. All research fellows and junior faculty members of the OUTCOMES RESEARCH Consortium are eligible. This year’s award was given to Priya Kumar, M.D. and Harry Arora, M.D. for their outstanding contributions to the POISE-2 and SIRS trials.
The Best Fellow Award is given to the Department of OUTCOMES RESEARCH fellow who is voted by the faculty to have performed at the very highest level. This year’s award was given to Yashar Eshraghi, M.D. for his remarkable contributions to several studies, including an evaluation of a novel non-invasive deep-temperature thermometer.
Active Grants
Funded Research - Peer Reviewed Sources
| Peer-Reviewed Sources | Agency | Principal Investigator | Direct cost ($) | Dates |
|---|---|---|---|---|
| The GAS study. Randomized controlled trial comparing regional and general anesthesia on neurodevelopmental outcome in infants | NIH | Szmuk | 117,493 | 2010-15 |
| Lung cancer biomarker evaluation | Joseph Drown Foundation | Sessler | 10,000 | 2012-13 |
| Development of a novel catheter | CCF Innovations | Elsharkawy | 5,000 | 2012 |
| Evaluation of A Novel Portable Simulator | FAER | Bustamante | 99,586 | 2013-14 |
| Anesthesia summer research fellowship | FAER | Hsieh | 4,200 | 2012 |
| Expanding the emerging collaboration perioperative medicine | Hamilton Health Sciences Research Strategic Initiative | Devereaux | 300,000 | 2012-14 |
| The Effect of Opioids on Chronic non-Cancer Pain: A Systematic Review and Meta-Analysis of Randomized Controlled Trials | Canadian Institutes of Health Research | Busse | 100,000 | 2012-13 |
| Informing Fresh versus Old Red cell Management (INFORM) | Canadian Institutes of Health Research | Eikelboom | 1,600,000 | 2012-16 |
| Peri-Operative ISchemic Evaluation-2 (POISE‑2) | Canadian Institutes of Health Research | Devereaux | 3,685,000 | 2012-16 |
| Remote IMPACT | Canadian Institutes of Health Research | Duncan | 33,700 | 2011- 16 |
| Evaluation of Multisource feedback in professionalism for anesthesia residents | FAER | Riveros-Perez | 100,000 | 2011-12 |
| Anesthesia summer research fellowship | FAER medical student fellowship | Schnetz | 4,200 | 2011 |
| HIP ATTACK: Hip fracture accelerated surgical treatment and care track | Hamilton Academic Health Sciences | Bhandari | 130,000 | 2011-12 |
| NeuroVISION: Neurological impact of vascular events in noncardiac surgery patients cohort evaluation | Canadian Institutes of Health Research | Mrkobrada | 85,000 | 2011-12 |
| Danyal Shaikh- NIHLB | NIHLB (R25HL103152) | Shaikh | 1,000 | 2011- 12 |
| Steroids in Cardiac Surgery | Population Health Research Institute | Yared | 78,200 | 2010-15 |
| Hyperinsulinemic glucose control and myocardial function during cardiac surgery | National Institutes of Health (K23HL093056) | Duncan | 493,000 | 2010-15 |
| Peri-Operative ISchemic Evaluation-2 | Population Health Research Institute | Kurz | 512,000 | 2010-14 |
| Perioperative cognitive protection — dexmedetomidine and cognitive reserve | National Institutes of Health (AG 029656) | Silverstein | 2,090,000 | 2007-12 |
| VISION | McMaster University | Kurz | 225,346 | 2011-13 |
| A Comparison of Epidural Analgesia and Traditional Pain Management Effects on Outcomes after Gastric Cancer Resection | CTSC | Cummings | 10,000 | 2012 |
| A Comparison of Epidural Analgesia and Traditional pain management | Case Western Reserve University | Cummings | 4,300 | 2010- 12 |
| Non-Contact ECG Monitoring ad Diagnosis | Cleveland State University | Ovreiu | 17,300 | 2010- 12 |
List includes grants on which an OUTCOMES RESEARCH Consortium member is a co-investigator; many are large multi-center projects in which the member investigator has a limited role. Amounts shown are totals for multi-year projects; funding for the current year is considerably less.
Corporate Sources
For collaborative projects, only funds controlled by OUTCOMES RESEARCH are included
| Corporate Sources | Agency | Principal Investigator | Direct cost ($) | Dates |
|---|---|---|---|---|
| Dexmedetomidine: Phase IV, Open-Label, Safety Study Evaluating the Use of Dexmedetomidine in Pediatric Subjects Undergoing Procedure-Type Sedation | Hospira Inc | Szmuk | 103,680 | 2012 |
| A Multicenter, Open-Label, Safety and Pharmacokinetic Study of Oral Codeine Sulfate Administration in Pediatric Subjects 2 years old through 17 years old with Post-procedural Pain | Roxane Laboratories Inc/Quintiles | Szmuk | 114,425 | 2012 |
| A Randomized, Placebo Controlled, Multi-Center Study of the Efficacy, Pharmacokinetics (PK) and Pharmacodynamics (PD) of Intravenous (IV) Acetaminophen for the treatment of Acute Pain in Pediatric Patients | Cadence Pharmaceuticals | Szmuk | 114,30 | 2012 |
| R.E.C.I.T.E. | Merck | Saager | 36,500 | 2012-13 |
| Outcomes Research Consortium Annual Meeting | Hospira | Sessler | 11,000 | 2012 |
| Safety of the Sufentanil NanoTab PCA System | AcelRX | Turan | 147,440 | 2012-13 |
| Protocol OTR3001. An Open-label, Multicenter Study of the Safety of Twice Daily Oxycodone | Purdue Pharma | Szmuk | 72,950 | 2011-12 |
| Protocol OTR3002. An Open-label, Extension Study to Assess the Long-Term Safety of Twice Daily Oxycodone Hydrochloride | Purdue Pharma | Szmuk | 58,648 | |
| EN3319-302 Non-randomized, Multicenter, Ascending Dose by Age, Single- and Multiple-Dose Evaluation of the Effectiveness, Safety, and Tolerability of Oral Liquid Oxymorphone | Endo Pharma | Szmuk | 269,990 | 2011-12 |
| Use of Rainbow Acoustic Monitor in Pediatric Patients | Masimo | Szmuk | 17,598 | 2011-12 |
| Incidence of Perioperative Anaphylactic Reactions | Merck | Saager | 234,000 | 2011-12 |
| Effect of Goal-directed Crystalloid versus Colloid Administration | Hospira | Kurz | 124,900 | 2011- 12 |
| A Multi Center Randomized open-label Surgical Surveillance | Cumberland Pharmaceutical | Turan | 58,400 | 2011- 12 |
| The effects of dexmedetomidine and propofol on cerebral blood flow | Hospira | Farag | 108,900 | 2010-12 |
| Remifentanil versus dexmedetomidine | Hospira | Rajan | 19,700 | 2010- 12 |
| A Multi-center, Randomized, Open-label, Surveillance Trial to Evaluate the Safety and Efficacy of a Shortened Infusion Time if Intravenous Ibuprofen | Cumberland | |||
| Pharma | Ayad | 38,068 | 2012 | |
| A Randomized Comparison of Pre-Warming with the Mistral-Air Convective Warming System | TSCI | Saager | 154,000 | 2012-15 |
| Real-time Ultrasound-guided Paramedian Epidural Access: Evaluation of a Novel in-plane Transverse View Technique | Pajunk Medical System | Zaky | 5,000 | 2012-15 |
| BIS and long-term outcomes | Aspect Medical | Sessler | 1,730,000 | 2009-13 |
| ASPECT Medical Data Collaborating Agreement | Aspect Medical | Sessler | 146,155 | 2008-13 |
| Breast Cancer Recurrence | Aspect Medical | 91,200 | 2008-13 | |
| Postoperative outcomes in patients who receive dexmedetomidine | Hospira | Turan | 18,500 | 2010- 12 |
| Dexlirium POCD BIS Sub-study | Aspect Medical | Sessler | 53,800 | 2009-14 |
List includes grants on which an OUTCOMES RESEARCH Consortium member is a co-investigator. Amounts shown are totals for multi-year projects; funding for the current year is considerably less.
Publications
Contribution to the world’s literature
A recent article by Pagel and Hudetz (BMC Anesthesiology 12:5, 2012) evaluates anesthesia publication trends. Their analysis was restricted to 14 English-language journals with an impact factor >1 which are the ones most likely to influence clinical practice. In 2010, the last year they report, there were 280 clinical research articles published. Last year, the Consortium published 28 papers in the 14 journals they considered. The Outcomes Research Consortium thus published a full 10% of the clinical research in high-profile general anesthesia journals. Of note, the Consortium also published an equal number of papers in specialty journals ranging from pain to critical care to neuroscience, and in major multi-specialty journals.
This year’s featured paper
Farag E, Sessler DI, Kovaci B, Wang L, Mascha EJ, Bell G, Kalfas I, Rockwood E, Kurz A: Effects of Crystalloid versus Colloid and the alpha-2 Agonist Brimonidine versus Placebo on Intraocular Pressure during Prone Spine Surgery: A Factorial Randomized Trial. Anesthesiology 2012; 116: 807-15
Background: Volume replacement with colloid solution and topical alpha-2 agonists may each moderate the progressive increase in intraocular pressure (IOP) during prone surgery. The authors tested the hypotheses that during prolonged prone surgery, IOP increases less with goal-directed intravenous administration of 5% albumin than with goal-directed administration of lactated Ringer's solution, and with topical alpha-2 agonist brimonidine than with placebo eye drops.
Methods: Patients having complex prone spine surgery were factorially randomized to albumin and topical placebo (n = 15); albumin and topical brimonidine (n = 16); lactated Ringer's solution and topical placebo (n = 13); and lactated Ringer's solution and topical brimonidine (n = 16). IOP was measured with a pneumotonometer. The primary outcome was time-weighted average intraoperative IOP.
Results: Prone positioning increased IOP a mean +/- SD of 12 +/- 6 mmHg. IOP increased to 38 +/- 10 mmHg at the end of anesthesia (approximately 5.5 h). Time- weighted average intraoperative IOP in the brimonidine group was 4 (95% CI: 1, 8) mmHg lower than in the placebo group (P = 0.023), but no different in the crystalloid and albumin groups (mean difference (95% CI) of -2 (-5, 2) mmHg (P = 0.34). There was no interaction between the two randomized factors.
Conclusions: Brimonidine slightly reduced the primary outcome of intraoperative time-weighted average IOP, whereas there was no significant difference between goal-directed albumin or crystalloid administration. Brimonidine thus helps reduce IOP during spine surgery, but maintaining adequate blood pressure might play a more important role.
Published Full Papers
1. Abd-Elsayed AA, Sessler DI, Mendoza-Cuartas M, Dalton JF, Said T, Meinert J, Upton G, Franklin C, Kurz A: A randomized controlled study to assess patients' understanding of and consenting for clinical trials using two different consent form presentations. Minerva anestesiologica 2012; 78: 564-73
2. Abdelmalak B, Ibrahim M, Yared JP, Modic MB, Nasr C: Perioperative Glycemic Management in Insulin Pump Patients Undergoing Noncardiac Surgery. Curr Pharm Des 2012
3. Abdelmalak B, Khanna A, Tetzlaff J: Fospropofol, A New Sedative Anesthetic, and its Utility in the Perioperative Period. Curr Pharm Des 2012
4. Abdelmalak BB, Gildea TR, Doyle DJ: Anesthesia for Bronchoscopy. Curr Pharm Des 2012
5. Adam F, Bordenave L, Sessler DI, Chauvin M: Effects of a single 1200-mg preoperative dose of gabapentin on anxiety and memory. Ann Fr Anesth Reanim 2012; 31: e223-e7
6. Adam F, Pelle-Lancien E, Bauer T, Solignac N, Sessler DI, Chauvin M: Anesthesia and postoperative analgesia after percutaneous hallux valgus repair in ambulatory patients. Ann Fr Anesth Reanim 2012; 31: e265-e8
7. Ahmad BU, Barakat MR, Feldman M, Singh RP: Bilateral subcutaneous emphysema from pressurized infusion during pars plana vitrectomy: A case report. Retin Cases Brief Rep 2012; 6: 22-4
8. Albeldawi M, Aggarwal A, Madhwal S, Cywinski J, Lopez R, Eghtesad B, Zein NN: Cumulative risk of cardiovascular events after orthotopic liver transplantation. Liver Transpl 2012; 18: 370-5
9. Apfel CC, Philip BK, Cakmakkaya OS, Shilling A, Shi YY, Leslie JB, Allard M, Turan A, Windle P, Odom-Forren J, Hooper VD, Radke OC, Ruiz J, Kovac A: Who is at risk for postdischarge nausea and vomiting after ambulatory surgery? Anesthesiology 2012; 117: 475-86
10. Argalious MY, Dalton JE, Cywinski JB, Seif J, Abdelmalak M, Sessler DI: Association between preoperative statin therapy and postoperative change in glomerular filtration rate in endovascular aortic surgery. Br J Anaesth 2012; 109: 161-7
11. Bauer M, George JE, Seif J, Farag E: Recent advances in epidural analgesia. Anesthesiology research and practice 2012; 2012: 1-14
12. Bauer M, Wang L, Onibonoje OK, Parrett C, Sessler DI, Mounir-Soliman L, Zaky S, Krebs V, Buller LT, Donohue MC, Stevens-Lapsley JE, Ilfeld BM: Continuous femoral nerve blocks: Decreasing local anesthetic concentration to minimize quadriceps femoris weakness. Anesthesiology 2012; 116: 665-72
13. Bienert A, Wiczling P, Grzeskowiak E, Cywinski JB, Kusza K: Potential pitfalls of propofol target controlled infusion delivery related to its pharmacokinetics and pharmacodynamics. Pharmacol Rep 2012; 64: 782-95
14. Chahar P, Cummings KC, 3rd: Liposomal bupivacaine: a review of a new bupivacaine formulation. J Pain Res 2012; 5: 257-64
15. Colvin LA, Fallon MT, Buggy DJ: Cancer biology, analgesics, and anaesthetics: is there a link? Br J Anaesth 2012; 109: 140-3
16. Conrick-Martin I, Kell MR, Buggy DJ: Meta-analysis of the effect of central neuraxial regional anesthesia compared with general anesthesia on postoperative natural killer T lymphocyte function. J Clin Anesth 2012; 24: 3-7
17. Cummings KC, 3rd, Xu F, Cummings LC, Cooper GS: A comparison of epidural analgesia and traditional pain management effects on survival and cancer recurrence after colectomy: A population-based study. Anesthesiology 2012; 116: 797-806
18. Demirjian S, Schold JD, Navia J, Mastracci TM, Paganini EP, Yared JP, Bashour CA: Predictive models for acute kidney injury following cardiac surgery. Am J Kidney Dis 2012; 59: 382-9
19. Devarajan J, Vydyanathan A, Xu M, Murthy SM, McCurry KR, Sessler DI, Sabik J, Bashour CA: Early tracheostomy is associated with improved outcomes in patients who require prolonged mechanical ventilation after cardiac surgery. J Am Coll Surg 2012; 214: 1008-16
20. Devereaux PJ, Chan MT, Alonso-Coello P, Walsh M, Berwanger O, Villar JC, Wang CY, Garutti RI, Jacka MJ, Sigamani A, Srinathan S, Biccard BM, Chow CK, Abraham V, Tiboni M, Pettit S, Szczeklik W, Lurati Buse G, Botto F, Guyatt G, Heels-Ansdell D, Sessler DI, Thorlund K, Garg AX, Mrkobrada M, Thomas S, Rodseth RN, Pearse RM, Thabane L, McQueen MJ, VanHelder T, Bhandari M, Bosch J, Kurz A, Polanczyk C, Malaga G, Nagele P, Le Manach Y, Leuwer M, Yusuf S: Association between postoperative troponin levels and 30-day mortality among patients undergoing noncardiac surgery. JAMA 2012; 307: 2295-304
21. Doherty M, Buggy DJ: Intraoperative fluids: how much is too much? Br J Anaesth 2012; 109: 69-79
22. Doufas AG, Panagiotou OA, Ioannidis JP: Concordance of sleep and pain outcomes of diverse interventions: an umbrella review. PLoS One 2012; 7: e40891
23. Edrich T, Cywinski JB, Colomina MJ, Jimenez Lopez I, Xiong L, Sedaghati A, Pomahac B, Gilton A: Perioperative management of face transplantation: a survey. Anesth Analg 2012; 115: 668-70
24. Elsharkawy HA, Galway U: Anesthetic management of direct laryngoscopy and dilatation of subglottic stenosis in a patient with severe myasthenia gravis. Case Reports in Anesthesiology 2012; 2012: 1-3
25. Farag E, Abd-Elsayed A, Anderson M, Abdelmalak J, Schubert A: Anesthetic management for Wingspan stent. Ochsner J 2012; 12: 30-4
26. Farag E, Abd-Elsayed A, Manno EM: Sensory evoked potentials and the search for the Holy Grail method to predict the outcome after hypoxic-ischemic coma. Minerva Anestesiol 2012; 78: 741-2
27. Farag E, Sessler DI, Kovaci B, Wang L, Mascha EJ, Bell G, Kalfas I, Rockwood E, Kurz A: Effects of crystalloid versus colloid and the alpha-2 agonist brimonidine versus placebo on intraocular pressure during prone spine surgery: A factorial randomized trial. Anesthesiology 2012; 116: 807-15
28. Grady MV, Mascha E, Sessler DI, Kurz A: The effect of perioperative intravenous lidocaine and ketamine on recovery after abdominal hysterectomy. Anesth Analg 2012; 115: 1078-84
29. Hata JS, Simmons JS, Kumar AB, Rickelman JH, Nickel EJ, Simmons ST, Torner J: The acute effectiveness and safety of the constant-flow, pressure-volume curve to improve hypoxemia in acute lung injury. J Intensive Care Med 2012; 27: 119-27
30. Haviv Y, Ezri T, Boaz M, Ivry S, Gurkan Y, Izakson A: Airway management practices in adult intensive care units in Israel: a national survey. J Clin Monit Comput 2012; 26: 415-21
31. Izakson A, T E, Weiner D, Litmanovich D, Khankin E: New developments in understanding of pathophysiology, diagnosis and treatment of severe acute pancreatitis. Jurnalul Român de Anestezie Terapie Intensivã 2012; 19: 39-50
32. Kavanagh T, Buggy DJ: Can anaesthetic technique effect postoperative outcome? Current Opinion in Anaesthesiology 2012; 25: 185-98
33. Kaw R, Pasupuleti V, Walker E, Ramaswamy A, Foldvary-Schafer N: Postoperative complications in patients with obstructive sleep apnea. Chest 2012; 141: 436-41
34. Koch CG, Li L, Hixson E, Tang A, Phillips S, Henderson JM: What are the real rates of postoperative complications: elucidating inconsistencies between administrative and clinical data sources. J Am Coll Surg 2012; 214: 798-805
35. Koch CG, Nowicki ER, Rajeswaran J, Gordon SM, Sabik JF, 3rd, Blackstone EH: When the timing is right: Antibiotic timing and infection after cardiac surgery. J Thorac Cardiovasc Surg 2012; 144: 931-7 e4
36. Kurz A, Sessler DI: HSR Proc Int Care & Cardiovasc Anesth. 2012; 1: 5-9
37. Liu N, Le Guen M, Benabbes-Lambert F, Chazot T, Trillat B, Sessler DI, Fischler M: Feasibility of Closed-loop Titration of Propofol and Remifentanil Guided by the Spectral M-Entropy Monitor. Anesthesiology 2012; 116: 286-95
38. Loor G, Li L, Sabik JF, 3rd, Rajeswaran J, Blackstone EH, Koch CG: Nadir hematocrit during cardiopulmonary bypass: end-organ dysfunction and mortality. J Thorac Cardiovasc Surg 2012; 144: 654-62 e4
39. Marcanthony N, Farag E: Intraoperative pontine infarction: a hidden challenge. Case Rep Anesthesiol 2012; 2012: 807398
40. Mascha EJ, Turan A: Joint hypothesis testing and gatekeeping procedures for studies with multiple endpoints. Anesthesia and analgesia 2012; 114: 1304-17
41. Ogurlu M, Orhan ME, Çinar S, Piri E, Kurt E, Sut N, Turan A: Effect of headphones on sevoflurane requirement for MRI. Pediatric Radiology 2012; 42: 1432-6
42. Ortner CM, Ruetzler K, Schaumann N, Lorenz V, Schellongowski P, Schuster E, Salem RM, Frass M: Evaluation of performance of two different chest tubes with either a sharp or a blunt tip for thoracostomy in 100 human cadavers. Scand J Trauma Resusc Emerg Med 2012; 20: 10
43. Parra-Sanchez I, Abdallah R, You J, Fu AZ, Grady M, Cummings K, 3rd, Apfel C, Sessler DI: A time-motion economic analysis of postoperative nausea and vomiting in ambulatory surgery. Can J anaesth 2012
44. Pattakos G, Koch CG, Brizzio ME, Batizy LH, Sabik JF, 3rd, Blackstone EH, Lauer MS: Outcome of patients who refuse transfusion after cardiac surgery: a natural experiment with severe blood conservation. Arch Intern Med 2012; 172: 1154-60
45. Podranski T, Bouillon TW, Riva T, Kurz AM, Oehmke MJ: Compartmental pharmacokinetics of nefopam during mild hypothermia. Br J Anaesth 2012; 108: 784-91
46. Rincón Valenzuela D, Caro A: Use of intra-operative supplemental oxygen to reduce morbidity and mortality in general anesthesia: systematic review and meta-analysis of randomized controlled trials. Colombian J Anesth 2012; 40: 34-51
47. Rincon-Valenzuela D: “We have never resigned ourselves to be mere craftsmen of anesthesia”: past, present and future of the Colombian Journal of Anesthesia. Colombian J Anesth 2012; 40: 6-7
48. Rizk MK, Tolba R, Kapural L, Mitchell J, Lopez R, Mahboobi R, Vrooman B, Mekhail N: Differential epidural block predicts the success of visceral block in patients with chronic visceral abdominal pain. Pain Pract 2012; 12: 595-601
49. Ruetzler K, Sima B, Mayer L, Golescu A, Dunkler D, Jaeger W, Hoeferl M, You J, Sessler DI, Grubhofer G, Hutschala D: Lidocaine/tetracaine patch (Rapydan) for topical anaesthesia before arterial access: a double-blind, randomized trial. Br J Anaesth 2012; 109: 790-6
50. Sessler DI, Kurz A: Departmental and institutional strategies for reducing fraud in clinical research. Anesth Analg 2012; 115: 474-6
51. Sessler DI, Sigl JC, Kelley SD, Chamoun NG, Manberg PJ, Saager L, Kurz A, Greenwald S: Hospital stay and mortality are increased in patients having a "Triple Low" of low blood pressure, low bispectral index, and low minimum alveolar concentration of volatile anesthesia. Anesthesiology 2012; 116: 1195-203
52. Shibasaki M, Nakajima Y, Shime N, Sawa T, Sessler DI: Prediction of optimal endotracheal tube cuff volume from tracheal diameter and from patient height and age: a prospective cohort trial. J Anesth 2012; 26: 536-40
53. Shimonov M, Protianov M, Blecher M, Schachter P, Landau O, Ezri T: Hemodynamic effects of laparoscopic radiofrequency ablation of liver tumors versus laparoscopic hepatic ultrasound examination. J Clin Anesth 2012; 24: 96-100
54. Steiner JW, Pop RB, You J, Hoang SQ, Whitten CW, Barden C, Szmuk P: Anesthesiology residents' medical school debt influence on moonlighting activities, work environment choice, and debt repayment programs: a nationwide survey. Anesth Analg 2012; 115: 170-5
55. Sulecki L, Dexter F, Zura A, Saager L, Epstein RH: Lack of value of scheduling processes to move cases from a heavily used main campus to other facilities within a health care system. Anesth Analg 2012; 115: 395-401
56. Treschan TA, Kaisers W, Schaefer MS, Bastin B, Schmalz U, Wania V, Eisenberger CF, Saleh A, Weiss M, Schmitz A, Kienbaum P, Sessler DI, Pannen B, Beiderlinden M: Ventilation with low tidal volumes during upper abdominal surgery does not improve postoperative lung function. Br J Anaesth 2012; 109: 263-71
57. Turan A, Dalton JE, Kasuya Y, Akca O, Sessler DI, Rauch S: Correlation between Bispectral Index, Observational Sedation Scale, and lower esophageal sphincter pressure in volunteers using dexmedetomidine or propofol. Med Sci Monit 2012; 18: CR593-6
58. Turan A, Shao D, Salmasi V, Honar H, Atim A, Dalton JE, Saager L, Sessler DI: Chemotherapy within 30 days before surgery does not augment postoperative mortality and morbidity. Can J Anaesth 2012; 59: 758-65
59. Turan A, You J, Shiba A, Kurz A, Saager L, Sessler DI: Angiotensin converting enzyme inhibitors are not associated with respiratory complications or mortality after noncardiac surgery. Anesth Analg 2012; 114: 552-60
60. Udeh CI, Udeh BL: The apples and oranges of cost-effectiveness: A rejoinder. Cleveland Clinic J Med 2012; 79: 608-10
61. Vegh T, Juhasz M, Enyedi A, Takacs I, Kollar J, Fulesdi B: Clinical experience with a new endobrochial blocker: the EZ-blocker. Journal of Anesthesia 2012; 26: 375-80
62. Wu J, You J, Yerian L, Shiba A, Schauer PR, Sessler DI: Prevalence of liver steatosis and fibrosis and the diagnostic accuracy of ultrasound in bariatric surgery patients. Obesity surgery 2012; 22: 240-7
63. Farag E, Abd-Elsayed A, Mascha EJ, O'Hara JF: Assessment of an anesthesiology academic department mentorship program. Ochsner J 2012; 12: 373-8
64. Kalkan, Y., et al.: The effect of rocuronium, sugammadex, and their combination on cardiac muscle and diaphragmatic skeletal muscle cells. J Anesth 2012; 26:870-877
65. Bignami, E., et al.Sevoflurane vs. propofol in patients with coronary disease undergoing mitral surgery: a randomised study. Acta Anaesthesiol Scand 2012; 56: 482-490
66. Kaw R, Chung F, Pasupuleti V, Mehta J, Gay PC, Hernandez AV: Meta-analysis of the association between obstructive sleep apnoea and postoperative outcome. Br J Anaesth 2012; 109: 897-906
Full Papers in press
1. Turan A, Mascha E, You J, Kurz A, Shiba A, Saager L, Sessler DI: Association between nitrous oxide and postoperative mortality and morbidity after non-cardiac surgery. Anesth Analg
2. Saager L, Turan A, Dalton JE, Figueroa P, Sessler DI, Kurz A: Red blood cell storage duration does not affect mortality in non-cardiac surgical patients: a retrospective analysis of 6,994 patients. Anesthesiology
3. Cata JP, Gottumukkala V, Sessler DI: How regional analgesia might reduce postoperative cancer recurrence. Eur J Pain
4. Rauch S, Krueger K, Turan A, You J, Roewer N, Sessler DI: Use of wireless motility capsule to determine gastric emptying and small intestinal transit times in critically ill patients. J Crit Care
5. Lindsay AJ, Xu M, Sessler DI, Blackstone EH, Bashour CA: Lactate clearance time and concentration linked to morbidity and mortality in cardiac surgery patients. Ann Thorac Surg
6. Goliasch G, Priemayr A, Fischer H, Frass M, Sessler DI, Ruetzler K: Evaluation of advanced airway manageement in absolutely inexperienced hands: a randomized manikin trial. Eur J Emerg Med
7. Abdelmalak B, Cata J, Bonilla A, You J, Kopyeva T, Vogel J, Campbell S, Sessler DI: Intraoperative tissue oxygenation and postoperative outcomes after major non-cardiac surgery: an observational study. Br J Anaesth
8. Komatsu R, You J, Mascha EJ, Sessler DI, Kasuya Y, Turan A: Anesthetic induction with etomidate, rather than propofol, is associated with increased 30-day mortality and cardiovascular morbidity after non-cardiac surgery. Anesth Analg
9. Sessler DI, Devereaux PJ: Emerging trends in clinical trial design. Anesth Analg
10. O’Hara JF, Mahboobi R, Novak SM, Bonilla AM, Mascha EJ, Fergany AF, Campbell SC, Kaouk JH, Kaple KM, Gill IS, Ziegman SA, Sessler DI: Fenoldopam and renal function following partial nephrectomy in a solitary kidney: A randomized, blinded trial. Urology
11. Turan A, Atim A, Dalton JE, Keeyapaj W, Chu W, Bernstein E, Fu A, Ho LJ, Saager L, Sessler DI: Preoperative angiotensin converting enzyme inhibitor use is not associated with increased postoperative pain or opioid use. Clin J Pain
12. Doufas AG, Orhan-Sungur M, Komatsu R, Lauber R, Akça O, Shafer SL, Sessler DI: Bispectral index dynamics during propofol hyponosis is similar in red-haired and dark-haired subjects. Anesth Analg
13. Ruetzler K, Fleck M, Nabecker S, Pinter K, Landskron G, Lessnigg A, You J, Sessler DI: Randomized, double-blind comparison of liquorice versus sugar-water gargle for prevention of postoperative sore throat and post-extubation coughing. Br J Anaesth
14. Sessler DI: The thermoregulation story. Anesthesiology in press
15. Abdelmalak B, Bonilla A, Mascha E, Maheshwari A, Tang WHW, You J, Ramachandran M, Kirkova Y, Clair D, Walsh M, Kurz A, Sessler DI: The Dexamethasone, Light Anaesthesia, and Tight Glucose Control (DeLiT) randomized controlled trial. Br J Anaesth
16. Végh T, Juhász M, Szatmári S, Enyedi A, Sessler DI, Szegedi LL, Fülesdi B: Effects of different tidal volumes for one-lung ventilation on oxygenation with open chest conditions and surgical manipulation: a randomized cross-over trial. Minerva Anesthesiologica
17. Le Guen M, Liu N, Bourgeois E, Chazot T, Sessler DI, Rouby JJ, Fischler M: Automated sedation outperforms manual administration of propofol and remifentanil in critically ill patients: a prospective randomized phase II trial. Anesthesiology
18. Ruetzler K Fleck M, Nabecker S, Pinter K, Landskron G, Lassnigg, A, You J, Sessler DI: Randomized, double-blind comparison of liquorice versus sugar-water gargle for prevention of postoperative sore throat and post-extubation coughing. Anesth Analg
19. Argalious MY, Dalton JE, Sreenivasalu T, O’Hara J, Sessler DI: Association of preoperative statin use and acute kidney injury after non-cardiac surgery. Anesth Analg
20. Akça O, Kurz A, Fleischmann E, Buggy D, Herbst F, Stocchi L, Galandiuk S, Iscoe S, Fisher J, Apfel CC, Sessler DI, and the Hypercapnia Trial Investigators: Hypercapnia and surgical site infection: A randomized trial. Br J Anaesth
21. Abdelmalak BB, Bonilla AM, Yang D, Chowdary HT, Gottlieb A, Lyden SP, Sessler DI: The hyperglycemic response to major non-cardiac surgery and the added effect of steroid administration in patients with and without diabetes. Anesth Analg
22. Farag E, Argalious M, Abd-Elsayed A, Ebrahim Z, Doyle DJ: The Use of Dexmedetomidine in Anesthesia and Intensive Care: A Review. Curr Pharm Des
23. Riveros R, Sung W, Sessler DI, Sanchez IP, Mascha EJ, Niezgoda J: Comparison of Truview PCD and GlideScopte to direct laryngoscopy in pediatric patients: a randomized trial. Can J Anaesth
24. Udeh CI, Diaz-Gómez JL, Anthony D, Satyapriya A, Perez-Protto S, Hata JS: Recent Advances in Perioperative Anesthetic Management Update on the Role of Vasopressin and its Effects on Outcomes. Curr Pharm Des
25. Douglas A, Convery E, Pickett P, Pickett P, Hata JS: Recent Advances in Perioperative Anesthetic Management Update in the Perioperative Support of Patients with Septic Shock and the Effect on Outcomes. Curr Pharm Des
26. Abdelmalak B; Lansang C: Revisiting tight glycemic control in perioperative and critically ill patients, when one size might not fit all, J Clin Anesth
27. Ulualp SO, Szmuk P. Drug-induced sleep endoscopy for upper airway evaluation in children with obstructive sleep apnea. Laryngoscope
28. Zangrillo A, Biondi Zoccai G, Landoni G, Frati G, Patroniti N, Pesenti A, Pappalardo F. et al: Extracorporeal membrane oxygenation (ECMO) in patients with H1N1 influenza infection: a systematic review and meta-analysis including 8 studies and 266 patients receiving ECMO. Crit care
29. Minai O, Yared, JP, Kaw R, Kathirvel S, Hill N. Perioperative risk and management in patients with pulmonary hypertension. Chest
30. Jaimchariyatam N, Dweik R, Kaw R, Aboussouan L. Polysomnographic Determinants of nocturnal hypercapnia in patients with sleep apnea. J Clin Sleep Med
Editorials
1. Devereaux PJ, Chan MT, Eisenach J, Schricker T, Sessler DI: The need for large clinical studies in perioperative medicine. Anesthesiology 2012; 116: 1169-75
2. Devereaux PJ, Sessler DI: The potential role of alpha-2 agonists for noncardiac surgery. Anesthesiology 2012; 116: 1192-4
3. Domino KB, Sessler DI: Internet use during Anesthesia: Does it matter? Anesthesiology 2012; 117: 1156-8
4. Larson MD, Sessler DI: Pupillometry to guide postoperative analgesia. Anesthesiology 2012; 116: 980-2
5. Saager L, Sessler DI: Targeted prophylaxis of postoperative delirium. Anesthesiology 2012; 116: 975-6
6. Kaw R. Postoperative complications in patients with obstructive sleep apnea. Clinics of Sleep Medicine, in press
7. Kaw R, Mokhlesi B. Acute aspects of sleep medicine. Sleep And Breathing, in press
Books
1. Farag E. Anesthesia for Spine Surgery. Cambridge: Cambridge University Press; 2012. 457 pgs.
2. Parat MO (ed) 2013, Morphine and metastasis, Springer, Dordrecht
3. Abdelmalak B, and Doyle J. Anesthesia for Otolaryngologic Surgery, Cambridge University press, London 2012, 353 pgs
Book Chapters
1. Could opioids affect cancer recurrence or metastases? Current experimental and translational evidence. Shanahan H., M.O. Parat, D. Buggy. In: Parat M.O., Ed. Morphine and metastasis, pp 79-94, 2013.
2. Morphine and metastasis: from bench to bedside. Parat M.O. In: Parat M.O., Ed. Morphine and metastasis, pp 1-13, 2013.
3. Abd-Elsayed AA, Farag E. Anesthesia for cervical spine surgery. In: Farag E, ed. Anesthesia for Spine Surgery. Cambridge: Cambridge University Press; 2012. Chapter 9. pp 178-187.
4. Abdelmalak B, Doyle DJ. Airway management in spine surgery. In: Farag E, ed. Anesthesia for Spine Surgery. Cambridge: Cambridge University Press; 2012. Chapter 4. pp 50-60.
5. Abdelmalak B, Riad I. Monitored anesthesia care and anesthesia outside the operating room. In: Longnecker DE, Brown DL, Newman MF, Zapol WM, eds. Anesthesiology. 2nd ed. New York , NY: McGraw-Hill Medical; 2012. Chapter 69. pp 1260-1274.
6. Avitsian R, Farag E. Neuroanesthesia. In: Longnecker DE, Brown DL, Newman MF, Zapol WM, eds. Anesthesiology. 2nd ed. New York, NY: McGraw-Hill Medical; 2012. Chapter 51. pp 869-898.
7. Bauer M, Kurz A, Farag E. Fluid management. In: Farag E, ed. Anesthesia for Spine Surgery. Cambridge: Cambridge University Press; 2012. Chapter 2. pp 25-42.
8. Cata JP, Zaky S. Postoperative acute pain. In: Farag E, ed. Anesthesia for Spine Surgery. Cambridge: Cambridge University Press; 2012. Chapter 18. pp 302-320.
9. Hata, TM and Hata, JS. Pre-anesthetic Evaluation and Preparation. In: Clinical Anesthesia. Editors: Barash, PG, Cullen, BF, and Stoelting, RK. Edition: Sixth. Publisher: Lippincott. 2013.
10. Noguera E, Burkey B, Abdelmalak B . Anesthesia for Flap Reconstruction, In : Abdelmalak B and Doyle DJ eds. Anesthesia for Otolaryngologic Surgery. London, UK , Cambridge University Press. Chapter 16. pp 151-162.
11. Khanna A, Wood B, Abdelmalak B . Anesthesia for Zenker’s diverticulum Surgery, In : Abdelmalak B and Doyle DJ eds. Anesthesia for Otolaryngologic Surgery. London, UK , Cambridge University Press. Chpater 20. pp 195-202
12. Abdelmalak B, Sarkiss M . Anesthesia for Advanced Diagnostic Bronchoscopic Procedures, In : Abdelmalak B and Doyle DJ eds. Anesthesia for Otolaryngologic Surgery. London, UK , Cambridge University Press. Chapter 30. pp 297-308
13. Abdelmalak B, Sarkiss M . Anesthesia for Therapeutic Bronchoscopic Procedures, In : Abdelmalak B and Doyle DJ eds. Anesthesia for Otolaryngologic Surgery. London, UK , Cambridge University Press. Chapter 31. pp 309-320
14. Sakhai H, Vidaurri L, Grover L, Kravitz B, Szmuk P. Use of inhalational anesthetics and neuromuscular blocking agents in the ICU. Stockwell JA and Pressing CM Editors. In: Society of Critical Care Medicine. Comprehensive Critical Care: Pediatric. Mt. Prospect, IL: Society of Critical Care Medicine; 2012. Chapter 91. pp 579-88
