Providing the evidence for evidence-based medicine©

 

2018 Annual Report

The OUTCOMES RESEARCH Group was formed in 1990 at the University of California in San Francisco and subsequently became an institute when the group's administrative center moved to the University of Louisville in March of 2000. In 2005, OUTCOMES RESEARCH became a department at the Cleveland Clinic. After 9 years, the Department of OUTCOMES RESEARCH now includes 65 members at the Clinic, among more than 130 academic investigators in fifteen countries including the Austria, Canada, China, Ireland, Israel, Japan, China, and the United States. The Consortium is non-profit; its only goal is thus participation in high-quality research.

2015 year was the Consortium’s 25th Anniversary. This milestone was celebrated by an editorial in Anesthesiology by Henry Rosenberg (2015; 123:1233-4). It starts: “IMAGINE a research group made up of more than 100 members working both independently and collaboratively across many countries having no legal standing, no bank account, and loosely organized, but devoted to the goal of improving health care through the understanding of the results of health care practices. Furthermore, imagine that members of this organization have published more than 900 full journal articles since its inception and publish a new full paper every 5 days. [The Consortium actually published a full paper every 3 days in 2017.] It may be hard to believe that such a unique organization exists, but it does. It is known as the OUTCOMES RESEARCH Consortium.”

The Consortium is currently involved in about 200 clinical studies, including many large multi-center outcome trials. Much of the Consortium’s funding is from the National Institutes of Health, the Canadian Institutes of Health Research, and other peer-reviewed granting agencies. We also collaborate with companies that make innovative devices and drugs, often conducting major trials that lead to regulatory certification. The Consortium facilitates scientific exchange and collaboration necessary for technically complex outcomes studies involving hundreds or thousands of patients. Additional information is available at www.OR.org.

Aspirations

Outcomes research seeks to understand the end results of particular health care practices and interventions. End results include effects that people experience and care about, such as change in the ability to function. In particular, for individuals with chronic conditions—where cure is not always possible—end results include quality of life as well as mortality. By linking the care people get to the outcomes they experience, outcomes research has become the key to developing better ways to monitor and improve the quality of care.

The general goal of the OUTCOMES RESEARCH Consortium is to evaluate inexpensive, low-risk interventions that are easy to implement yet likely to markedly improve outcome. For example, we have shown that simply maintaining intraoperative normothermia markedly reduces the risk of complications — and does so at trivial cost. A consequence of our work is that active intraoperative warming has become routine, whereas it was rare a decade ago.

Mission

Be the world’s leading anesthesia-related clinical research organization.

Behaviors

1. Publish more high-impact, peer-reviewed clinical research papers (quantified as number times impact) than any other anesthesia organization.

2. Recruit more extra-mural clinical research funding than any other anesthesia organization, with “clinical research” being defined as research conducted with human subjects.

3. Train clinical investigators at all levels.

Personnel

Administrative Structure

Director: Daniel I. Sessler, M.D. Cleveland USA
Associate Director: Andrea Kurz, M.D. Cleveland USA

2018 Site Directors

Donal Buggy, M.D. Dublin Ireland
Tibi Ezri, M.D. Tel Aviv Israel
Peter Szmuk, M.D. Dallas USA
Yuguang Huang, M.D. Beijing China
Thomas Volk, M.D. Homburg Germany
Colin Royse, M.D. Melbourne Australia
Brian Ilfeld, M.D. San Diego USA
Alparslan Turan, M.D. Cleveland USA

General Members

Member City Country
Alaa A. Abd-Elsayed, M.D.MadisonUSA
Basem B. Abdelmalak, M.D.ClevelandUSA
Janet Adegboye, B.S.ClevelandUSA
Sanchit Ahuja, M.D.DetroitUSA
Ozan Akca, M.D.LouisvilleUSA
Assad Ali, B.S.ClevelandUSA
Sibs Anwar, M.D., Ph.D.LondonUnited Kingdom
Harendra Arora, M.D.Chapel HillUSA
Amanda Artis, M.S.ClevelandUSA
Valentina Assenzo, M.D.Suresnes, ParisFrance
Abdulkadir Atim, M.D.AnkaraTurkey
Sabry Ayad, M.D.ClevelandUSA
Rovnat Babazade, M.D.GalvestonUSA
Gausan Bajracharya, M.D.ClevelandUSA
Allen Bashour, M.D.ClevelandUSA
Beatrice Beck-Schimmer, MDZurichSwitzerland
Sergio D. Bergese, M.D.ColumbusUSA
Bruce M. Biccard, M.B.Ch.B., F.C.A., Ph.D.Cape TownSouth Africa
Peter Biro, M.D.ZurichSwitzerland
Joshua A. Bloomstone, M.D., M.ScPlantationUSA
James M. Blum, M.D.DecaturUSA
Hagen Bomberg, M.D.HomburgGermany
Mauro Bravo, M.DClevelandUSA
Donal J. Buggy, M.D., FRCPI, FRCACSI, FRCADublinIreland
Juan Cata, M.D.HoustonUSA
Praveen Chahar, M.D., F.C.A.R.C.S.I.ClevelandUSA
Christine Chang, B.S.ClevelandUSA
David Chelnick, B.S.ClevelandUSA
Surendrasingh S. Chhabada, M.D.ClevelandUSA
Praneeta Chodavarapu, M.D.CincinnatiUSA
Barak Cohen, M.D.ClevelandUSA
Allen CollinsClevelandUSA
Jennifer CookClevelandUSA
Jacek B. Cywinski, M.D.ClevelandUSA
Jarrod E. Dalton, Ph.D.ClevelandUSA
Gildasio S. De Oliveira Jr., M.D., M.S.C.I.ProvidenceUSA
Stacie G. Deiner, M.D.New YorkUSA
Anthony G. Doufas, M.D., Ph.D.StanfordUSA
Andra E. Duncan, M.D.ClevelandUSA
Ruthy Edry, M.D.HaifaIsrael
Proshad N. Efune, M.D.DallasUSA
Kavita Elliott, B.S.ClevelandUSA
Hesham Elsharkawy, M.D.ClevelandUSA
Hani Essber, M.D.ClevelandUSA
Tibi Ezri, M.D.HolonIsrael
Jonathan Fang, M.D.ClevelandUSA
Ehab S.A. Farag, M.D., F.R.C.A.ClevelandUSA
Mary FedericoClevelandUSA
Tobias Fink, M.D.HomburgGermany
John J. Finneran IV, M.D.San DiegoUSA
Edith Fleischmann, M.D.ViennaAustria
Béla Fülesdi, M.D., Ph.D.DebrecenHungary
Rodney A. Gabriel, M.D.La JollaUSA
Marcelo Gama de Abreu, M.D., M.Sc., Ph.D.DresdenGermany
Martin V. Grady, M.D.Mayfield HeightsUSA
Sarah Guirguis, M.D.ClevelandUSA
Sven Halvorson, M.S.ClevelandUSA
Hassan Hamadnalla, M.D.ClevelandUSA
CeCelia HanlineClevelandUSA
Manal Hassan, M.D.Mayfield HeightsUSA
Mohamed Hassan, M.D.ClevelandUSA
Steve Hata, M.D., F.C.C.P., M.S.C.ClevelandUSA
Adam Hochman, B.S.ClevelandUSA
Yuguang Huang, M.D.BeijingChina
Tobias Hüppe, M.D.Homnburg (Saar)Germany
Brian M. Ilfeld, M.D., M.S.San DiegoUSA
Ilker Ince, M.D.ClevelandUSA
Steven R. Insler, D.O.ClevelandUSA
Daniela C. Ionescu, Ph.D., D.E.A.A.Cluj-NapocaRomania
Tadahiko Ishiyama, M.D., Ph.D.ChuoJapan
Pia Jaeger, M.D., Ph.D.CopenhagenDenmark
Jens-Ulrik S. Jensen, M.D., Ph.D.CopenhagenDenmark
Roberta JohnsonClevelandUSA
Barbara Kabon, M.D.ViennaAustria
Yusuke Kasuya, M.D.TokyoJapan
Elliott KavitaclevelandUSA
Roop Kaw, M.D.ClevelandUSA
Mohammad Zafeer Khan, M.D.ClevelandUSA
Ashish K. Khanna, M.D., F.C.C.P., F.C.C.M.ClevelandUSA
Sandeep Khanna, M.D.ClevelandUSA
Dilara Khoshknabi, M.D.ClevelandUSA
Oliver Kimberger, M.D.ViennaAustria
Ryu Komatsu, M.D.SeattleUSA
Onur Koyuncu, M.D. Turkey
Sascha Kreuer, M.D.HomburgGermany
Priya A. Kumar, M.D.Chapel HillUSA
Andrea M. Kurz, M.D.ClevelandUSA
Giovanni Landoni, M.D.MilanItaly
Rana K. Latif, M.D., F.C.A.I.LouisvilleUSA
Kate Leslie, M.D., F.A.N.Z.C.A.ParkvilleAustralia
Chen Liang, M.S.ClevelandUSA
Liu Liu, M.A.ClevelandUSA
Ngai Liu, M.D., Ph.D.SuresnesFrance
Vladimir V. Lomivorotov, M.D., Ph.D.NovosibirskRussia
Dominik Lorenz, M.D.Homburg / SaarGermany
Chao Ma, M.S.ClevelandUSA
Anthony T. Machi, M.D.DallasUSA
Kamal Maheshwari, M.D.ClevelandUSA
Natalya Makarova, M.S.ClevelandUSA
Guangmei Mao, M.S.ClevelandUSA
Lilit Margaryan, M.D.ClevelandUSA
Edward J. Mascha, Ph.D.ClevelandUSA
Takashi Matsukawa, M.D.ChuoJapan
Felix Maurer, B.S.HomburgGermany
Diana Mehanny, M.D.ClevelandUSA
Miluska Mejia, M.D.ClevelandUSA
Mark MettlerClevelandUSA
Scott A. Miller, M.D.Winston SalemUSA
Paul MinkoClevelandUSA
Toshiki Mizobe, M.D., Ph.D.KyotoJapan
Zhirajr Mokini, M.D.MonzaItaly
Sohail Mulla, M.Sc.HamiltonCanada
Yasuko Nagasaka, M.D., Ph.D.TokyoJapan
Yasufumi Nakajima, M.D., Ph.D.HirakataJapan
Amanda Naylor, B.A.ChicagoUSA
Azfar Niazi, M.D.ClevelandUSA
Ben O’Brian, M.D., Ph.D., M.H.B.A., F.R.C.A.LondonUnited Kingdom
Detlef E.R. Obal, M.D., Ph.D., D.E.S.A.SanfordUSA
Makoto Ozaki, M.D., Ph.D.TokyoJapan
Marie-Odile Parat, Pharm.D., Ph.D.WoolloongabbaAustralia
Lijian Pei, M.D.BeijingChina
Silvia E. Perez-Protto, M.D., M.S.ClevelandUSA
Reuven Pizov, M.D.JerusalemIsrael
Olga M. Plattner, M.D.ViennaAustria
Kanhaiya Poddar, M.D.ClevelandUSA
Attila Podolyak, M.D.ClevelandUSA
Yuwei Qiu, M.D.ClevelandUSA
Shobana Rajan, M.D.ClevelandUSA
Yussef RazaClevelandUSA
David A. Rincón-Valenzuela, M.D., M.Sc.BogotáColombia
Eva Rivas Ferreira, M.D.ClevelandUSA
Efrain Riveros-Perez, M.D.AugustaUSA
Reitze N. Rodseth, M.B.Ch.B., F.C.A., M.Med.DurbanSouth Africa
Colin Royse, M.D.MelbourneAustralia
Kurt Ruetzler, M.D.ClevelandUSA
Remie Saab, M.D.ClevelandUSA
Leif Saager, M.D.Ann ArborUSA
Wael Saasouh, M.D.DetroitUSA
Partha Saha, M.D.ClevelandUSA
Ogena Saied, M.S.ClevelandUSA
Ahmed Salih, M.D.ClevelandUSA
Vafi Salmasi, M.D.Palo AltoUSA
Bernd Saugel, M.D. E.D.I.C.HamburgGermany
Yehoshua-Nadav Schacham, M.D.Ramat-GanIsrael
Martin Schläpfer, M.D., M.Sc.ZurichSwitzerland
Thomas P. Schricker, M.D., Ph.D.MontrealCanada
Nanette M. Schwann, M.D.AllentownUSA
Daniel I. Sessler, M.D.ClevelandUSA
Tetsuya Shimada, M.D.ClevelandUSA
Akhil K. Singh, M.B.B.S., M.D.New DelhiIndia
Abraham Sonny, M.D.BostonUSA
Jeff W. Steiner, D.O.DallasUSA
Matthew W. Swisher, M.D., M.S.La JollaUSA
Peter Szmuk, M.D.DallasUSA
Erika Taco-Vasquez, M.D.ClevelandUSA
Marianne Tanios, M.D.ClevelandUSA
Abdullah S. Terkawi, M.D.CharlottesvilleUSA
Uchida Tokujiro, M.D., Ph.D.TokyoJapan
David Torres, M.D.SantiagoChile
Alparslan Turan, M.D.ClevelandUSA
Tamás Végh, M.D., Ph.D.DebrecenHungary
Thomas Volk, M.D.HomburgGermany
Anupama Wadhwa, M.D.San DiegoUSA
Michael WaltersClevelandUSA
Catherine I. Wang, M.D.BeijingChina
Jason Wu, M.D.ShanghaiChina
Lexie Xu, M.D.BeijingChina
Dongsheng Yang, M.S.ClevelandUSA
Jean-Pierre Yared, M.D.ClevelandUSA
Oguz Yilmaz, M.D. Turkey
Kan Zhang, M.D.ClevelandUSA

Research Fellows

Name Origin Dates Subsequent Position
NameOriginDatesSubsequent Position
Steven Leung, M.D.USA2015-18Radiology residency, Cleveland Clinic
Azfar Niazi, M.D.Pakistan2015-
Gausan Bajracharya, M.D.Nepal2016-18Anesthesia residency, Cleveland Clinic
Sanchit Ahuja, M.D.India2016-18Anesthesia residencey, Henry Ford Hospital
Kan Zhang, M.D.Japan2016-18Anesthesia residency, Cleveland Clinic
Partha Saha, M.D.India2016-
Barak Cohen, M.D.Israel2016-19
Miluska Mejia, M.D.Peru2017-18Anesthesia residency, University of Rochester
Eva Rivas, M.D.Spain2017-
Myra Ahmed, M.D.Egypt2017-18
Erika Taco-Vasquez, M.D.Ecuador2018-
Sarah Guiguis, M.D.USA2017-
Lillit Marggaryan, M.D.Armenia2017-18Medicine residency, Cincinnati Christ Hospital
Dianna Mehanny, M.D.USA2017-
Marianne Tanios, M.D.Egypt2017-
Dilara Khoshknabi, M.D.Azerbaijan2017-
Remie Saab, M.D.Lebanon2017-
Hani Essbr, M.D.Syria2017-
Mohammed Zafeer-Khan, M.D.India2017-
Ahmed Salih, M.D.Iraq2018-
Jonathan Fang, M.D.USA2018-
Hassan Hamadnalla, M.D.Egypt2018-
Ilker Ince, M.D.Turkey2018-
Mohamad Hassan, M.D.Egypt2018-
Yuwei Qiu, M.D.China2018-
Tetsuya Shimada, M.D.Japan2018-

Graduate and Medical Students (full year)

Name Origin Dates Subsequent Position
Logan Glosser, B.A.USA2016-18University of Toledo Medical School
David Chelnick, B.S.USA2017-
Yousuf Raza, B.S.Pakastan2017-
Assad Ali, B.S.USA2017-
Kavita Elliott, B.S.USA2017-
CeCelia Hanline, M.H.S.USA2017-
Paul Minko, B.S.USA2017-
Lauretta Mosteller, B.S.USA2018-
Adam Hochman, M.S.USA2018-Medical College of South Carolina
Michael Walters, B.S.USA2017-18Cleveland Clinic Lerner College of Medicine
Janet Adegboye, B.S.USA2018-19Cleveland Clinic Lerner College of Medicine

Honors and Awards

Name Honor Organization
Ben O’BrianHonorary ProfessorWilliam Harvey Research Institute
Rovnat BabazadeBest of MeetingWorld Congress on Regional Anesthesia & Pain Med
Kurt RuetzlerElectedAssociation of University Anesthesiologists
Sabry AyadMBACleveland State University
Bernd SaugelChair, Scientific Subcommittee 14European Society of Anaesthesiology
Alparslan TuranResearch award named in his honorTurkish Society of Anesthesia
Ashish KhannaElected memberAssociation of University Anesthesiologists

Consortium Research Awards

The Gladys Sessler Prize is an endowed award that is given yearly. All research fellows and junior faculty members of the OUTCOMES RESEARCH Consortium are eligible. This year’s award was to Barak Cohen.

The Best Fellow Award is given to the Department of OUTCOMES RESEARCH fellow who is voted by the faculty to have performed at the very highest level. This year’s award was given to Gausan Bajracharya.

Active Grants

Peer-Reviewed Sources Agency Principal Investigator Direct cost ($) Dates
Testing and Commercialization of a Superior Device to Maintain Perioperative Normothermia In Anesthetized PatientsNational Institutes of Health (R42GM119871)Sessler11500002018-20
Improving Postamputation Functioning by Decreasing Phantom Limb Pain and Opioid Use with Perioperative Continuous Peripheral Nerve Blocks: A Multicenter RCTDepartment of Defense Congressionally Directed Medical Research ProgramsIlfeld28470002017-21
Cryoanalgesia to Treat Postamputation Phantom Limb Pain: A Definitive Clinical Trial Department of Defense Congressionally Directed Medical Research ProgramsIlfeld39500002017-21
Ultrasound-guided Percutaneous Peripheral Nerve Stimulation: A Non-Pharmacologic Alternative for the Treatment of Postoperative Pain [Pilot Study]Department of Defense Congressionally Directed Medical Research ProgramsIlfeld15327742018-20
Ultrasound-guided Percutaneous Peripheral Nerve Stimulation: A Non-Pharmacologic Alternative for the Treatment of Postoperative Pain [Definitive Clinical Trial]Department of Defense Congressionally Directed Medical Research ProgramsIlfeld54385632020-24
A Randomized, Double-Blinded, Placebo-Controlled, Multicenter Pilot Study of the SMARTPATCH Peripheral Nerve Stimulation (PNS) System for the Treatment of Post-Amputation PainDepartment of Defense Congressionally Directed Medical Research Programs [W81XWH-12-2-0132] Primary: SPR Therapeutics Subaward: Ilfeld$2,770,156 (Prime) and $126,679 (Subward)2015-2019
Improving Functional Outcomes of Combat-Injured Warfighters by Relieving Post-Amputation Pain Using NerveSpaceDepartment of Defense Congressionally Directed Medical Research Programs W81XWH-17-C-0019Primary: SPR Therapeutics Subaward: Ilfeld$5,973,138 (Prime) and $320,763 (Subward)2018-2021
Summer Student StipendFAERDreyer42002018
Recovery from Pain and Disability after Surgery National Institutes of Health (P01GM113852)Eisenach (Sessler Lead Investigator for Project 3)41470002016-21
PeriOperative ISchemic Evaluation-3 (POISE-3)Canadian Institutes of Health ResearchDevereaux36850002018-22
SMArT VIEW: CoVeRed: TecHnology Enabled remote monitoring and Self-MAnagemenT - Vision for patient EmpoWerment following Cardiac and VasculaR surgery.Canadian Institutes of Health ResearchMcGillion8000002015-19
Hyperinsulinemic glucose control and myocardial function during cardiac surgeryNational Institutes of Health (K23HL093056)Duncan7225002010-16
Treating Intractable Post Amputation Phantom Limb Pain with Ambulatory Continuous peripheral Nerve BlocksDOD W81XWH-13-2-009Ilfeld26170002012-20
A Prospective Case Series Study of SPR Peripheral Nerve Stimulation (PNS) Therapy for the Treatment of Pain following Total Knee Arthroplasty (TKA) Utilizing Pre-operative Lead PlacementNational Institutes of Health 1R44AG052196Ilfeld [subaward]1721612015-18
A Randomized, Double-Blinded, Placebo-Controlled, Multicenter Pilot Study of the SMARTPATCH Peripheral Nerve Stimulation (PNS) System for the Treatment of Post-Amputation PainDOD W81XWH-12-2-0132Ilfeld [subaward]3308432015-17
Improving Functional Outcomes of Combat-Injured Warfighters by Relieving Post-Amputation Pain Using NerveSpaceDOD W81XWH-17-C-0019Ilfeld [subaward]2500002015-18
A Randomized Controlled Trial of Regional Versus General Anesthesia For Promoting Independence After Hip Fracture (REGAIN Trial)PCORI PCS-1406-18876Neuman [subaward]1698282015-present
Electrical stimulation to reduce pain and improve function after TKANational Institutes of Health Boggs21210002015-18
Perioperative Lidocaine in cancer recurrence: next steps in defining its biological plausibility BJA international grantBuggy1700002017-18
PAIN-STOP Preventing pAIn with Nmda antagonists-Steroids in Thoracoscopic lObectomy ProceduresPopulation Health Research InstituteTuran198232018-
Treating Intractable Post Amputation Phantom Limb Pain with Ambulatory Continuous peripheral Nerve BlocksDODIlfeld26170002012-20
Corporate Sources Agency Principal Investigator Direct cost ($) Dates
SHARPFresenius-KabiDuncan2416072014-2018
PRODIGYCovidienKhanna3715772017-18
Association between IOH and AKI after non-cardiac surgeryEdwards LifesciencesSessler615382018-
A Validation of the Assisted Fluid Management FeatureEdwards LifesciencesMaheshwari1556642018-
Pectoralis and Serratus Muscle Blocks for Analgesia After Minimally Invasive Cardiac ProceduresPaciraAlfirevic3457622018-
A Comparison of Combined Pectoral Fascial Plane and Serratus Nerve Blocks with Liposomal or Plain Bupivacaine for Video Assisted Thoracic SurgeryPaciraMarciniak3467782018-
Medical Records: Comparison of Asian and Caucasian surgical patients on analgesic and safety outcomes using liposomal bupivacaine (Exparel®): a retrospective matched-cohort analysisPaciraTuran1458502018-
A Prospective, Comparative Effectiveness Randomized Controlled Trial of SPR peripheral nerve stimulation (PNS) therapy for the treatment of pain following total knee arthroplasty (TKA) utilizing preoperative lead placementSPR TherapeuticsElsharkawy650942018-
The Role of Acumen Hypotension Prediction Index Software in Hypotension Management During Moderate to High-Risk Non-cardiac SurgeryEdwards LifesciencesMaheshwari3996552018-
Sugammadex versus neostigmine for reversal of rocuronium neuromuscular block in patients having catheter-based neurointerventional proceduresMerckFarag1263792017-present
A Randomized, Double-Blind, Placebo-Controlled, Multicenter Evaluation of the Safety of N1539 Following Major SurgeryRecro PharmaAyad813392017-present
A Multicenter, Prospective, Parallel-Group, Double-Blind, Randomized, Placebo-Controlled, Phase 2 Study of BB3 to Assess the Safety and Efficacy of BB3 in Patients Developing Acute Kidney Injury after Cardiac Surgery (Angion)AngionAyad4264992017-present
Protocol DevelopmentAttuneSessler250002017-18
Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy, Safety, and Pharmacokinetics of Femoral Nerve Block with EXPAREL for Postsurgical Analgesia in Subjects Undergoing Total Knee ArthroplastyPaciraAyad1885392017-2018
Ancillary Effects of Oral Naloxegol (Movantik)AstraZenecaTuran1949702017-
Longitudinal Psychometric Evaluation of a Novel Patient-Reported Measure to Assess Physical Functioning Following Hip Fracture RepairRTI Health SolutionsTuran111192017-2018
Dose and safety of Liposomal bupivacaine (Exparel) for surgical wound infiltration during open surgical procedures in pediatric surgical patients: a retrospective cohort analysisPaciraTuran3604652017-2018
The Use of Exparel in Pediatric SurgeryPaciraTuran218502017-2018
Prediction of Opiod-Induced Respiratory Depression (PRODIGY)CovidenKhanna3715772017-18
PeRioperative HypOTErmia and myoCardial injury afTer non-cardiac surgery (PROTECT)3MSessler13500002016-18
Patient Worn Temperature Sensor PatchWelch-AllynSessler656252016-2018
The Role of Noninvasive Beat-to-Beat Clearsight Blood Pressure Monitoring During Non-cardiac SurgeryEdwards LifesciencesMaheshwari2680002016-18
A Randomized, Double-Blind, Placebo Controlled, Phase 2 Study to Evaluate the Efficacy and Safety of QPI-1002 for the Prevention of Acute Kidney Injury in Subjects at High Risk for AKI following Cardiac SurgeryQuark Pharmaceuticals Ayad1581352016-2018
Effect of Needle Guidance in Paravertebral Ultrasound Guided block, Cadaveric StudyCIVCOElsharkawy307692016-2018
A Placebo-Controlled Trial of SABER-Bupivacaine for the Management of Postoperative Pain Following Laparoscopic Cholecystectomy (PERSIST)Durect Corp Ayad1549002016-2018
Mild hypothermia and MINS randomized trial3M Sessler17000002016-19
A Randomized Controlled Trial to Determine the effect of Gabapentin Enacarbil on Opioid Consumption and Pain Scores in Patients having Hip and Knee Arthroplasties with Spinal AnesthesiaXenoportAyad2041012015-2019
Comparison of Bilateral Transversus Abdominis Plane Block with Exparel verus Continuous Epidural Analgesia with Bupivacaine: A Randoized, Controlled TrialPaciraTuran13786802015-
Pharmacokinetics of PhenylephrineWestwardChhabada1281322015-present
A Phase 3, Placebo-Controlled, Randomized, Double-Blind, Multi-Center Study of LJPC-501 in Patients with Catecholamine-Resistant Hypotension (CRH)La JollaKhanna3419612015-2018
A Multi-center, Randomized, Double-Blind, Placebo-Controlled, Adaptive Design Study Evaluating the Analgesic Efficacy and Safety of Intravenous CR845 in Patients Undergoing Abdominal SurgeryCara TherapeuticsAyad3227922015-2018
PK/PD Effects on Blood Pressure Following IV Phenylephrine AdministrationWestwardSzmuk871102015-18
The Incidence and Severity of Postoperative Hypoxemia and Hypotension, and the Extent to Which Each is Missed by the Current Clinical Monitoring RoutineSotera WirelessSessler1524002015-2018
Evaluation of SEDLine EEG monitoring in pediatric patients undergoing General Anesthesia or SedationMasimoSzmuk634402015-18
Effect of Goal - Directed Crystalloid Versus Colloid Administration on Major Postoperative MorbidityFreseniusKurz2052242015-2018
Multi-Center Open Label Single Dose and Placebo Controlled Multi Dose Oxymorphone trialEndoSzmuk2300362016-19
Comparison of the McGrath videolaryngoscopy and direct laryngoscopy for intubation in morbid obese patients MedtronicRuetzler1301702017-18
A Phase 4 Controlled Trial to Study the Efficacy and Safety of Sugammadex (MK-8616) for the Reversal of Neuromuscular Blockade Induced by Either Rocuronium Bromide or Vecuronium Bromide in Morbidly Obese SubjectsMerckRuetzler2517002017-18
Effect of Intravenous Acetaminophen on Postoperative Opioid-related ComplicationsMallinckrodtTuran5981132013-2018
Ancillary Effects of Dexmedetomidine Sedation After Cardiac SurgeryPfizerTuran5245132012-2018
Safety of 1 g of Cefazolin in Pediatric Subjects Scheduled for SurgeryB.BraunSzmuk2000002018
Pharmokinetics and safety of oxycodone in childrenVistaPharmaSzmuk1150002018
Ascending Dose, Study to Determine the Pharmacokinetics of Phenylephrine and the Pharmacodynamic Effects on Blood Pressure in Pediatric SubjectsWest WardSzmuk2100002018
Oxymorphone for severe pain in pediatric surgical patientsEndo PharmaceuticalsSzmuk1150002018
Safety and Tolerability of Subcutaneous Administration of Fremanezumab in Pediatric Migraine PatientsTEVASzmuk730002018
The Videolaryngoscopy in Small Infants (VISI) TrialCHOPSzmuk190002018
A Phase 4 Randomized, Active-Comparator Controlled Trial to Study the Efficacy and Safety of Sugammadex (MK-8616) for the Reversal of Neuromuscular Blockade MK-8616-1066MerckRutzler2840002018-19

List includes grants on which an OUTCOMES RESEARCH Consortium member is a co-investigator. Amounts shown are totals for multi-year projects; funding for the current year is considerably less.

Publications

Contribution to the world’s literature

An article by Pagel and Hudetz (BMC Anesthesiology 12:5, 2012) evaluated anesthesia publication trends. Their analysis was restricted to 14 English-language journals with an impact factor >1 which are the ones most likely to influence clinical practice. In 2010, the last year they report, there were 280 clinical research articles published. Last year, the Consortium published 41 papers in the 14 journals they considered. The Outcomes Research Consortium thus publishes more than 10% of the clinical research in high-profile general anesthesia journals. Of note, the Consortium also publishes nearly as many papers in specialty journals ranging from pain to critical care to neuroscience, and in major multi-specialty journals. Overall, the Consortium publishes a full paper or editorial every 3 days.

Since inception, the Consortium has published more than 1,300 full papers.

Featured on journal covers this year

This year’s featured papers

Kurz A, Kopyeva T, Suliman I, Podolyak A, You J, Lewis B, Vlah C, Khatib R, Keebler A, Reigert R, Seuffert M, Muzie L, Drahuschak S, Gorgun E, Stocchi L, Turan A, Sessler DI: Supplemental oxygen and surgical-site infections: an alternating intervention controlled trial. Br J Anaesth 2018; 120: 117-26

Background: The main defense against bacterial infection is oxidative killing by neutrophils which requires molecular oxygen in wounded tissues. High inspired oxygen fractions increase tissue oxygenation. But whether improving tissue oxygenation actually reduces surgical site infection remains controversial. We therefore tested the primary hypothesis that supplemental oxygen (80% versus 30%) reduces the risk of a 30-day composite of deep tissue or organ-space surgical sites infection, healing-related wound complications, and mortality.

Methods: In an isolated suite of operating rooms, inspired oxygen concentration was alternated between 30% and 80% at two-week intervals for 39 months. Analysis was restricted to patients who had major intestinal surgery lasting at least two hours. 5,749 qualifying operations were analysed, including 2,843 (49%) colorectal resections, 1,866 (32%) lower GI therapeutic procedures, 373 (6%) small bowel resections, and 667 (13%) other colorectal procedures.

Findings: The 80% and 30% oxygen groups were well balanced on all of the demographic, baseline, and procedural variables. The oxygen intervention had no effect on the collapsed composite primary outcome or any of its components. The overall observed incidence of the composite outcome was 10.8% (314/2,896) in the 80% oxygen group and 11.0% (314/2,853) in the 30% group. The estimated relative risk was 0.99 (95% CI: 0.85, 1.14) for 80% versus 30%, P = 0.85.

Interpretation: Clinicians should not give supplemental oxygen in an effort to prevent major infection and healing-related complications after major intestinal surgery.

Published Full Papers

1. Abdelmalak BB, Abd-Elsayed AA, Dalton JE, Abdelmalak JB, Lawrence JP, Doyle DJ, Schreiber MJ, Sear JW: The association between preinduction arterial blood pressure and postoperative cardiovascular, renal, and neurologic morbidity, and in-hospital mortality in elective noncardiac surgery: an observational study. J Hypertens 2018; 36: 2251-9

2. Abril MK, Khanna AK, Kroll S, McNamara C, Handisides D, Busse LW: Regional differences in the treatment of refractory vasodilatory shock using Angiotensin II in High Output Shock (ATHOS-3) data. J Crit Care 2018; 50: 188-94

3. Assenzo V, Assenzo C, Filippo R, Le Guen M, Sage E, Roux A, Fischler M, Liu N: The feasibility of extubation in the operating room after bilateral lung transplantation in adult emphysema patients: an observational retrospective study. Eur J Cardiothorac Surg 2018; 54: 1128-33

4. Ayas NT, Laratta CR, Coleman JM, Doufas AG, Eikermann M, Gay PC, Gottlieb DJ, Gurubhagavatula I, Hillman DR, Kaw R, Malhotra A, Mokhlesi B, Morgenthaler TI, Parthasarathy S, Ramachandran SK, Strohl KP, Strollo PJ, Twery MJ, Zee PC, Chung FF, A. T. S. Assembly on Sleep, Respiratory N: Knowledge gaps in the perioperative management of adults with obstructive sleep apnea and obesity hypoventilation syndrome. An official American Thoracic Society workshop report. Ann Am Thorac Soc 2018; 15: 117-26

5. Beattie WS, Wijeysundera DN, Chan MTV, Peyton PJ, Leslie K, Paech MJ, Sessler DI, Wallace S, Myles PS, Galagher W, Farrington C, Ditoro A, Baulch S, Sidiropoulos S, Bulach R, Bryant D, O'Loughlin E, Mitteregger V, Bolsin S, Osborne C, McRae R, Backstrom M, Cotter R, March S, Silbert B, Said S, Halliwell R, Cope J, Fahlbusch D, Crump D, Thompson G, Jefferies A, Reeves M, Buckley N, Tidy T, Schricker T, Lattermann R, Iannuzzi D, Carroll J, Jacka M, Bryden C, Badner N, Tsang MWY, Cheng BCP, Fong ACM, Chu LCY, Koo EGY, Mohd N, Ming LE, Campbell D, McAllister D, Walker S, Olliff S, Kennedy R, Eldawlatly A, Alzahrani T, Chua N, Sneyd R, McMillan H, Parkinson I, Brennan A, Balaji P, Nightingale J, Kunst G, Dickinson M, Subramaniam B, Banner-Godspeed V, Liu J, Kurz A, Hesler B, Fu AY, Egan C, Fiffick AN, Hutcherson MT, Turan A, Naylor A, Obal D, Cooke E, Anzca Clinical Trials Network for the ENIGMA-II Investigators: Implication of major adverse postoperative events and myocardial injury on disability and survival: A planned subanalysis of the ENIGMA-II trial. Anesth Analg 2018; 127: 1118-26

6. Bialka S, Copik M, Daszkiewicz A, Rivas E, Ruetzler K, Szarpak L, Misiolek H: Comparison of different methods of postoperative analgesia after thoracotomy-a randomized controlled trial. J Thorac Dis 2018; 10: 4874-82

7. Bialka S, Copik M, Rybczyk K, Owczarek A, Jedrusik E, Czyzewski D, Filipowski M, Rivas E, Ruetzler K, Szarpak L, Misiolek H: Assessment of changes of regional ventilation distribution in the lung tissue depending on the driving pressure applied during high frequency jet ventilation. BMC Anesthesiol 2018; 18: 101

8. Biccard BM, Scott DJA, Chan MTV, Archbold A, Wang CY, Sigamani A, Urrutia G, Cruz P, Srinathan SK, Szalay D, Harlock J, Tittley JG, Rapanos T, Elias F, Jacka MJ, Malaga G, Abraham V, Berwanger O, Montes FR, Heels-Ansdell DM, Hutcherson MT, Chow CK, Polanczyk CA, Szczeklik W, Ackland GL, Dubois L, Sapsford RJ, Williams C, Cortes OL, Le Mananch Y, Devereaux PJ: Myocardial injury after noncardiac surgery (MINS) in vascular surgical patients: A prospective observational cohort study. Ann Surg 2018; 268: 357-63

9. Biccard BM, Sigamani A, Chan MTV, Sessler DI, Kurz A, Tittley JG, Rapanos T, Harlock J, Szalay D, Tiboni ME, Popova E, Vasquez SM, Kabon B, Amir M, Mrkobrada M, Mehra BR, El Beheiry H, Mata E, Tena B, Sabate S, Zainal Abidin MK, Shah VR, Balasubramanian K, Devereaux PJ: Effect of aspirin in vascular surgery in patients from a randomized clinical trial (POISE-2). Br J Surg 2018; 105: 1591-7

10. Bielski A, Rivas E, Ruetzler K, Smereka J, Puslecki M, Dabrowski M, Ladny JR, Frass M, Robak O, Evrin T, Szarpak L: Comparison of blind intubation via supraglottic airway devices versus standard intubation during different airway emergency scenarios in inexperienced hand: Randomized, crossover manikin trial. Medicine (Baltimore) 2018; 97: e12593

11. Bomberg H, Bayer I, Wagenpfeil S, Kessler P, Wulf H, Standl T, Gottschalk A, Doffert J, Hering W, Birnbaum J, Spies C, Kutter B, Winckelmann J, Liebl-Biereige S, Meissner W, Vicent O, Koch T, Sessler DI, Volk T, Raddatz A: Prolonged catheter use and infection in regional anesthesia: A retrospective registry analysis. Anesthesiology 2018; 128: 764-73

12. Bomberg H, Meiser F, Zimmer S, Bellgardt M, Volk T, Sessler DI, Groesdonk HV, Meiser A: Halving the volume of AnaConDa: initial clinical experience with a new small-volume anaesthetic reflector in critically ill patients-a quality improvement project. J Clin Monit Comput 2018; 32: 639-46

13. Bomberg H, Paquet N, Huth A, Wagenpfeil S, Kessler P, Wulf H, Wiesmann T, Standl T, Gottschalk A, Doffert J, Hering W, Birnbaum J, Kutter B, Winckelmann J, Liebl-Biereige S, Meissner W, Vicent O, Koch T, Burkle H, Sessler DI, Raddatz A, Volk T: Epidural needle insertion : A large registry analysis. Anaesthesist 2018; 67: 922-30

14. Bomberg H, Wetjen L, Wagenpfeil S, Schope J, Kessler P, Wulf H, Wiesmann T, Standl T, Gottschalk A, Doffert J, Hering W, Birnbaum J, Kutter B, Winckelmann J, Liebl-Biereige S, Meissner W, Vicent O, Koch T, Burkle H, Sessler DI, Volk T: Risks and benefits of ultrasound, nerve stimulation, and their combination for guiding peripheral nerve blocks: A retrospective registry analysis. Anesth Analg 2018; 127: 1035-43

15. Bowyer AJ, Heiberg J, Sessler DI, Newman S, Royse AG, Royse CF: Validation of the cognitive recovery assessments with the Postoperative Quality of Recovery Scale in patients with low-baseline cognition. Anaesthesia 2018; 73: 1382-91

16. Buse GL, Manns B, Lamy A, Guyatt G, Polanczyk CA, Chan MTV, Wang CY, Villar JC, Sigamani A, Sessler DI, Berwanger O, Biccard BM, Pearse R, Urrutia G, Szczeklik RW, Garutti I, Srinathan S, Malaga G, Abraham V, Chow CK, Jacka MJ, Tiboni M, Ackland G, Macneil D, Sapsford R, Leuwer M, Le Manach Y, Devereaux PJ: Troponin T monitoring to detect myocardial injury after noncardiac surgery: a cost-consequence analysis. Can J Surg 2018; 61: 185-94

17. Busse JW, Wang L, Kamaleldin M, Craigie S, Riva JJ, Montoya L, Mulla SM, Lopes LC, Vogel N, Chen E, Kirmayr K, De Oliveira K, Olivieri L, Kaushal A, Chaparro LE, Oyberman I, Agarwal A, Couban R, Tsoi L, Lam T, Vandvik PO, Hsu S, Bala MM, Schandelmaier S, Scheidecker A, Ebrahim S, Ashoorion V, Rehman Y, Hong PJ, Ross S, Johnston BC, Kunz R, Sun X, Buckley N, Sessler DI, Guyatt GH: Opioids for chronic noncancer pain: A systematic review and meta-analysis. JAMA 2018; 320: 2448-60

18. Canty DJ, Heiberg J, Yang Y, Royse AG, Margale S, Nanjappa N, Scott D, Maier A, Sessler DI, Chuan A, Palmer A, Bucknill A, French C, Royse CF: Pilot multi-centre randomised trial of the impact of pre-operative focused cardiac ultrasound on mortality and morbidity in patients having surgery for femoral neck fractures (ECHONOF-2 pilot). Anaesthesia 2018; 73: 428-37

19. Chamoun GF, Li L, Chamoun NG, Saini V, Sessler DI: Comparison of an updated risk stratification index to hierarchical condition categories. Anesthesiology 2018; 128: 109-16

20. Cinamon U, Gavish D, Ovnat Tamir S, Goldfarb A, Ezri T: Effect of general anesthesia and intubation on parathyroid levels in normal patients and those with hyperparathyroidism. Head Neck 2018; 40: 555-60

21. Cohen B, Schacham YN, Ruetzler K, Ahuja S, Yang D, Mascha EJ, Barclay AB, Hung MH, Sessler DI: Effect of intraoperative hyperoxia on the incidence of surgical site infections: a meta-analysis. Br Journal Anaesth 2018; 120: 1176-86

22. Cotoia A, Mirabella L, Beck R, Matrella P, Assenzo V, Chazot T, Cinnella G, Liu N, Dambrosio M: Effects of closed-loop intravenous anesthesia guided by Bispectral Index in adult patients on emergence delirium: a randomized controlled study. Minerva Anestesiol 2018; 84: 437-46

23. Csongradi A, Enyedi A, Takacs I, Vegh T, Manyine IS, Polik Z, Altorjay IT, Balla J, Balla G, Edes I, Kappelmayer J, Toth A, Papp Z, Fagyas M: Optimized angiotensin-converting enzyme activity assay for the accurate diagnosis of sarcoidosis. Clin Chem Lab Med 2018; 56: 1117-25

24. Cummings KC, Zimmerman NM, Maheshwari K, Cooper GS, Cummings LC: Epidural compared with non-epidural analgesia and cardiopulmonary complications after colectomy: A retrospective cohort study of 20,880 patients using a national quality database. J Clin Anesth 2018; 47: 12-8

25. D’Ercole F, Arora H, Kumar PA: Paravertebral block for thoracic surgery. Journal of Cardiothoracic and Vascular Anesthesia 2018; 32: 915-27

26. Devereaux PJ, Duceppe E, Guyatt G, Tandon V, Rodseth R, Biccard BM, Xavier D, Szczeklik W, Meyhoff CS, Vincent J, Franzosi MG, Srinathan SK, Erb J, Magloire P, Neary J, Rao M, Rahate PV, Chaudhry NK, Mayosi B, de Nadal M, Iglesias PP, Berwanger O, Villar JC, Botto F, Eikelboom JW, Sessler DI, Kearon C, Pettit S, Sharma M, Connolly SJ, Bangdiwala SI, Rao-Melacini P, Hoeft A, Yusuf S, Investigators M: Dabigatran in patients with myocardial injury after non-cardiac surgery (MANAGE): an international, randomised, placebo-controlled trial. Lancet 2018; 391: 2325-34

27. Disma N, O'Leary JD, Loepke AW, Brambrink AM, Becke K, Clausen NG, De Graaff JC, Liu F, Hansen TG, McCann ME, Salorio CF, Soriano S, Sun LS, Szmuk P, Warner DO, Vutskits L, Davidson AJ: Anesthesia and the developing brain: A way forward for laboratory and clinical research. Paediatr Anaesth 2018; 28: 758-63

28. Disma N, Withington D, McCann ME, Hunt RW, Arnup SJ, Izzo F, de Graaff JC, Mattioli G, Morton N, Frawley G, Davidson A, Lynn A, Szmuk P, Thomas JJ, Ragg P, Pini Prato A: Surgical practice and outcome in 711 neonates and infants undergoing hernia repair in a large multicenter RCT: Secondary results from the GAS Study. J Pediatr Surg 2018; 53: 1643-50

29. Duceppe E, Yusuf S, Tandon V, Rodseth R, Biccard BM, Xavier D, Szczeklik W, Meyhoff CS, Franzosi MG, Vincent J, Srinathan SK, Parlow J, Magloire P, Neary J, Rao M, Chaudhry NK, Mayosi B, de Nadal M, Popova E, Villar JC, Botto F, Berwanger O, Guyatt G, Eikelboom JW, Sessler DI, Kearon C, Pettit S, Connolly SJ, Sharma M, Bangdiwala SI, Devereaux PJ: Design of a randomized placebo-controlled trial to assess dabigatran and omeprazole in patients with myocardial injury after noncardiac surgery (MANAGE). Can J Cardiol 2018; 34: 295-302

30. Duncan AE: GIK: The cure we have been waiting for? (editorial). Anesth Analg 2018; 126: 1121-3

31. Duncan AE, Sessler DI, Sato H, Sato T, Nakazawa K, Carvalho G, Hatzakorzian R, Codere-Maruyama T, Abd-Elsayed A, Bose S, Said T, Mendoza-Cuartas M, Chowdary H, Mascha EJ, Yang D, Gillinov AM, Schricker T: Hyperinsulinemic normoglycemia during cardiac surgery reduces a composite of 30-day mortality and serious in-hospital complications: A randomized clinical trial. Anesthesiology 2018; 128: 1125-39

32. Efune PN, Minhajuddin A, Szmuk P: Incidence and factors contributing to postdischarge nausea and vomiting in pediatric ambulatory surgical cases. Paediatr Anaesth 2018; 28: 257-63

33. Elsharkawy H, Barnes T, Babazade R, Huarte M, Ali Sakr Esa W, Ilfeld BM: Preliminary experience with epidural and perineural catheter localization with pulsed wave Doppler ultrasonography. Minerva Anestesiol 2018; 84: 803-10

34. Elsharkawy H, Kashy BK, Babazade R, Gray AT: Ultrasound detection of arteria comitans: A novel technique to locate the sciatic nerve. Reg Anesth Pain Med 2018; 43: 57-61

35. Elsharkawy H, Maniker R, Bolash R, Kalasbail P, Drake RL, Elkassabany N: Rhomboid intercostal and subserratus plane block: A cadaveric and clinical evaluation. Reg Anesth Pain Med 2018; 43: 745-51

36. Elsharkawy H, Pawa A, Mariano ER: Interfascial plane blocks: Back to basics. Reg Anesth Pain Med 2018; 43: 341-6

37. Elsharkawy H, Saasouh W, Patel B, Babazade R: Ultrasound pulsed-wave doppler detects an intrathecal location of an epidural catheter tip: A case report. A A Pract 2018; 10: 176-8

38. Ezri T, Waintrob R, Avelansky Y, Izakson A, Dayan K, Shimonov M: Pre-selection of primary intubation technique is associated with a low incidence of difficult intubation in patients with a BMI of 35 kg/m(2) or higher. Rom J Anaesth Intensive Care 2018; 25: 25-30

39. Farag E: Dexmedetomidine: A multifaceted drug in perioperative medicine (editorial). J Clin Anesth 2018; 55: 1-2

40. Graham MM, Sessler DI, Parlow JL, Biccard BM, Guyatt G, Leslie K, Chan MTV, Meyhoff CS, Xavier D, Sigamani A, Kumar PA, Mrkobrada M, Cook DJ, Tandon V, Alvarez-Garcia J, Villar JC, Painter TW, Landoni G, Fleischmann E, Lamy A, Whitlock R, Le Manach Y, Aphang-Lam M, Cata JP, Gao P, Terblanche NCS, Ramana PV, Jamieson KA, Bessissow A, Mendoza GR, Ramirez S, Diemunsch PA, Yusuf S, Devereaux PJ: Aspirin in patients with previous percutaneous coronary intervention undergoing noncardiac surgery. Ann Intern Med 2018; 168: 237-44

41. Henley MD, Kumar PA: Quadricuspid aortic valve or a rare complication of cocaine abuse? J Cardiothorac Vasc Anesth 2018; 32: 1533-5

42. Ilfeld BM, Gabriel RA, Said ET, Monahan AM, Sztain JF, Abramson WB, Khatibi B, Finneran JJt, Jaeger PT, Schwartz AK, Ahmed SS: Ultrasound-guided percutaneous peripheral nerve stimulation: Neuromodulation of the sciatic nerve for postoperative analgesia following ambulatory foot surgery, a proof-of-concept study. Reg Anesth Pain Med 2018; 43: 580-9

43. Itenov TS, Johansen ME, Bestle M, Thormar K, Hein L, Gyldensted L, Lindhardt A, Christensen H, Estrup S, Pedersen HP, Harmon M, Soni UK, Perez-Protto S, Wesche N, Skram U, Petersen JA, Mohr T, Waldau T, Poulsen LM, Strange D, Juffermans NP, Sessler DI, Tonnesen E, Moller K, Kristensen DK, Cozzi-Lepri A, Lundgren JD, Jensen JU, Cooling, Surviving Septic Shock Trial Collaboration: Induced hypothermia in patients with septic shock and respiratory failure (CASS): a randomised, controlled, open-label trial. Lancet Respir Med 2018; 6: 183-92

44. Ivascu NS, Shen L, Noguera E, Flynn BC: Noteworthy literature published in 2017 for cardiac critical care. Semin Cardiothorac Vasc Anesth 2018; 22: 18-26

45. Jaeger P, Baggesgaard J, Sorensen JK, Ilfeld BM, Gottschau B, Graungaard B, Dahl JB, Odgaard A, Grevstad U: Adductor canal block with continuous infusion versus intermittent boluses and morphine consumption: A randomized, blinded, controlled clinical trial. Anesth Analg 2018; 126: 2069-77

46. Jentzer JC, Vallabhajosyula S, Khanna AK, Chawla LS, Busse LW, Kashani KB: Management of refractory vasodilatory shock. Chest 2018; 154: 416-26

47. Johnson MZ, Crowley PD, Foley AG, Xue C, Connolly C, Gallagher HC, Buggy DJ: Effect of perioperative lidocaine on metastasis after sevoflurane or ketamine-xylazine anaesthesia for breast tumour resection in a murine model. Br J Anaesth 2018; 121: 76-85

48. Kalasbail P, Makarova N, Garrett F, Sessler DI: Heating and cooling rates with an esophageal heat exchange system. Anesth Analg 2018; 126: 1190-5

49. Karimi N, Kelava M, Kothari P, Zimmerman NM, Gillinov AM, Duncan AE: Patients at high risk for obstructive sleep apnea are at increased risk for atrial fibrillation after cardiac surgery: A cohort analysis. Anesth Analg 2018; 126: 2025-31

50. Khanna AK: Searching for better outcomes in septic shock trials (editorial). J Crit Care 2018; 47: 331-2

51. Khanna AK: Defending a mean arterial pressure in the intensive care unit: Are we there yet? (editorial). Ann Intensive Care 2018; 8: 116

52. Khanna AK, Naylor DF, Jr., Naylor AJ, Mascha EJ, You J, Reville EM, Riter QM, Diwan M, Kurz A, Sessler DI: Early resumption of beta blockers is associated with decreased atrial fibrillation after noncardiothoracic and nonvascular surgery: A cohort analysis. Anesthesiology 2018; 129: 1101-10

53. Khanna AK, Overdyk FJ, Greening C, Di Stefano P, Buhre WF: Respiratory depression in low acuity hospital settings-Seeking answers from the PRODIGY trial. J Crit Care 2018; 47: 80-7

54. Khanna S, Argalious M: CON: Revised Cardiac Risk Index Should Be Used in Preference to American College of Surgeons National Surgical Quality Improvement Program Surgical Risk Calculator for Estimating Cardiac Risk in Patients Undergoing Noncardiac Surgery. J Cardiothorac Vasc Anesth 2018; 32: 2420-2

55. Khanna S, Maheshwari K: Hemopericardium and acute cardiac tamponade. Anesthesiology 2018; 128: 1006

56. Komatsu R, You J, Rajan S, Kasuya Y, Sessler DI, Turan A: Steroid administration after anaesthetic induction with etomidate does not reduce in-hospital mortality or cardiovascular morbidity after non-cardiac surgery. Br J Anaesth 2018; 120: 501-8

57. Koyuncu O, Hakimoglu S, Ugur M, Akkurt C, Turhanoglu S, Sessler D, Turan A: Acetaminophen reduces acute and persistent incisional pain after hysterectomy. Ann Ital Chir 2018; 89: 357-66

58. Kranke P, Bergese SD, Minkowitz HS, Melson TI, Leiman DG, Candiotti KA, Liu N, Eberhart L, Habib AS, Wallenborn J, Kovac AL, Diemunsch P, Fox G, Gan TJ: Amisulpride prevents postoperative nausea and vomiting in patients at high risk: A randomized, double-blind, placebo-controlled trial. Anesthesiology 2018; 128: 1099-106

59. Kumar A, Abdelmalak B, Inoue Y, Culver DA: Pulmonary alveolar proteinosis in adults: pathophysiology and clinical approach. Lancet Resp Med 2018; 6: 554-65

60. Kurz A, Kopyeva T, Suliman I, Podolyak A, You J, Lewis B, Vlah C, Khatib R, Keebler A, Reigert R, Seuffert M, Muzie L, Drahuschak S, Gorgun E, Stocchi L, Turan A, Sessler DI: Supplemental oxygen and surgical-site infections: an alternating intervention controlled trial. Br J Anaesth 2018; 120: 117-26

61. Maheshwari K, Khanna S, Bajracharya GR, Makarova N, Riter Q, Raza S, Cywinski JB, Argalious M, Kurz A, Sessler DI: A randomized trial of continuous noninvasive blood pressure monitoring during noncardiac surgery. Anesth Analg 2018; 127: 424-31

62. Maheshwari K, Nathanson BH, Munson SH, Khangulov V, Stevens M, Badani H, Khanna AK, Sessler DI: The relationship between ICU hypotension and in-hospital mortality and morbidity in septic patients. Intensive Care Med 2018; 44: 857-67

63. Maheshwari K, Planchard J, You J, Sakr WA, George J, Higuera-Rueda CA, Saager L, Turan A, Kurz A: Early surgery confers 1-year mortality benefit in hip-fracture patients. J Orthop Trauma 2018; 32: 105-10

64. Maheshwari K, Turan A, Mao G, Yang D, Niazi AK, Agarwal D, Sessler DI, Kurz A: The association of hypotension during non-cardiac surgery, before and after skin incision, with postoperative acute kidney injury: a retrospective cohort analysis. Anaesthesia 2018; 73: 1223-8

65. Mascha EJ: Identifying the best cut-point for a biomarker, or not (editorial). Anesth Analg 2018; 127: 820-2

66. Maurer F, Shopova T, Wolf B, Kiefer D, Hüppe T, Volk T, Sessler DI, Kreuer S: Design and validation of an automated solid phase extraction liquid chromatography coupled mass spectrometry method for the quantification of propofol in plasma. J Pharmaceutical Biomedical Analysis 2018; 150: 341-6

67. McEvoy MD, Thies KC, Einav S, Ruetzler K, Moitra VK, Nunnally ME, Banerjee A, Weinberg G, Gabrielli A, Maccioli GA, Dobson G, O'Connor MF: Cardiac arrest in the operating room: Part 2-Special situations in the perioperative period. Anesth Analg 2018; 126: 889-903

68. Mekhail N, Azer G, Saweris Y, Mehanny DS, Costandi S, Mao G: The impact of tobacco cigarette smoking on spinal cord stimulation effectiveness in chronic spine–related pain patients. Regional Anesthesia and Pain Medicine 2018

69. Michard F, Sessler DI: Ward monitoring 3.0 (editorial). Br J Anaesth 2018; 121: 999-1001

70. Michard F, Sessler DI, Saugel B: Non-invasive arterial pressure monitoring revisited. Intensive Care Med 2018; 44: 2213-5

71. Moitra VK, Einav S, Thies KC, Nunnally ME, Gabrielli A, Maccioli GA, Weinberg G, Banerjee A, Ruetzler K, Dobson G, McEvoy MD, O'Connor MF: Cardiac arrest in the operating room: Resuscitation and management for the anesthesiologist: Part 1. Anesth Analg 2018; 126: 876-88

72. Mrkobrada M, Chan MTV, Cowan D, Spence J, Campbell D, Wang CY, Torres D, Malaga G, Sanders RD, Brown C, Sigamani A, Szczeklik W, Dmytriw AA, Agid R, Smith EE, Hill MD, Sharma M, Sharma M, Tsai S, Mensinkai A, Sahlas DJ, Guyatt G, Pettit S, Copland I, Wu WKK, Yu SCH, Gin T, Loh PS, Ramli N, Siow YL, Short TG, Waymouth E, Kumar J, Dasgupta M, Murkin JM, Fuentes M, Ortiz-Soriano V, Lindroth H, Simpson S, Sessler D, Devereaux PJ: Rationale and design for the detection and neurological impact of cerebrovascular events in non-cardiac surgery patients cohort evaluation (NeuroVISION) study: a prospective international cohort study. BMJ Open 2018; 8: e021521

73. Mukai N, Nakayama Y, Ishi S, Ogawa S, Maeda S, Anada N, Murakami S, Mizobe T, Sawa T, Nakajima Y: Changes in MicroRNA Expression Level of Circulating Platelets Contribute to Platelet Defect After Cardiopulmonary Bypass. Crit Care Med 2018; 46: e761-e7

74. Mukai N, Nakayama Y, Murakami S, Tanahashi T, Sessler DI, Ishii S, Ogawa S, Tokuhira N, Mizobe T, Sawa T, Nakajima Y: Potential contribution of erythrocyte microRNA to secondary erythrocytosis and thrombocytopenia in congenital heart disease. Pediatr Res 2018; 83: 866-73

75. Myles PS, Boney O, Botti M, Cyna AM, Gan TJ, Jensen MP, Kehlet H, Kurz A, De Oliveira GS, Peyton P, Sessler DI, Tramèr MR, Wu CL, Myles P, Grocott M, Biccard B, Blazeby J, Boney O, Chan M, Diouf E, Fleisher L, Kalkman C, Kurz A, Moonesinghe R, Wijeysundera D: Systematic review and consensus definitions for the Standardised Endpoints in Perioperative Medicine (StEP) initiative: patient comfort. Br J Anaesth 2018; 120: 705-11

76. Ni Eochagain A, Burns D, Riedel B, Sessler DI, Buggy DJ: The effect of anaesthetic technique during primary breast cancer surgery on neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and return to intended oncological therapy. Anaesthesia 2018; 73: 603-11

77. Palczynski P, Bialka S, Misiolek H, Copik M, Smelik A, Szarpak L, Ruetzler K: Thyromental height test as a new method for prediction of difficult intubation with double lumen tube. PLoS One 2018; 13: e0201944

78. Pei L, Huang Y, Mao G, Sessler DI: Axillary temperature, as recorded by the iThermonitor WT701, well represents core temperature in adults having noncardiac surgery. Anesth Analg 2018; 126: 833-8

79. Pei L, Huang Y, Xu Y, Zheng Y, Sang X, Zhou X, Li S, Mao G, Mascha EJ, Sessler DI: Effects of ambient temperature and forced-air warming on intraoperative core temperature: A factorial randomized trial. Anesthesiology 2018; 128: 903-11

80. Perez-Protto S, Nazemian R, Matta M, Patel P, Wagner KJ, Latifi SQ, Lebovitz DJ, Reynolds JD: The effect of inhalational anaesthesia during deceased donor organ procurement on post-transplantation graft survival. Anaesth Intensive Care 2018; 46: 178-84

81. Perez-Protto SE, Reynolds JD, Nazemian R, You J, Hata JS, Latifi SQ, Lebovitz DJ: Peripheral tissue oxygenation and the number of organs transplanted per donor. Anaesth Intensive Care 2018; 46: 601-7

82. Presta MV, Bhavani SS, Abdelmalak BB: Nil per os guidelines: what is changing, what is not, and what should? Minerva Anestesiol 2018; 84: 1413-9

83. Puebla I, Noll E, Diemunsch S, Pottecher J, Rameaux J-P, Diana M, Sauleau E, Ruetzler K, Diemunsch P: Prevention of laparoscopic surgery induced hypothermia with warmed humidified insufflation: Is the experimental combination of a warming blanket synergistic? Plos One 2018; 13

84. Puslecki M, Ligowski M, Kiel M, Dabrowski M, Stefaniak S, Sip M, Maciejewski A, Dabrowska A, Kiel-Puslecka I, Klosiewicz T, Misterski M, Buczkowski P, Szarpak L, Ruetzler K, Perek B, Czekajlo M, Jemielity M: Prototype of extracorporeal membrane oxygenation (ECMO) therapy simulator used in regional ECMO program. J Thorac Dis 2018; 10: 5073-9

85. Rao VK, Khanna AK: Postoperative respiratory impairment is a real risk for our patients: The intensivist's perspective. Anesthesiol Res Pract 2018; 2018: 3215923

86. Rivas E, Venegas JG, Rodríguez-Roisin R: Can the lung be obese? The effects of bariatric surgery on lung function and imaging. Barcelona Respiratory Network 2018; 4

87. Riveros-Perez E, McClendon J, Xiong J, Cheriyan T, Rocuts A: Anesthetic and obstetric outcomes in pregnant women undergoing cesarean delivery according to body mass index: Retrospective analysis of a single-center experience. Ann Med Surg (Lond) 2018; 36: 129-34

88. Ruetzler K, Lin P, You J, Schacham Y, Naylor AJ, Sessler DI, Saager L: The association between timing of routine preoperative blood testing and a composite of 30-day postoperative morbidity and mortality. Anesth Analg 2018; 127: 897-903

89. Saager L, Maiese EM, Bash LD, Meyer TA, Minkowitz H, Groudine S, Philip BK, Tanaka P, Gan TJ, Rodriguez-Blanco Y, Soto R, Heisel O: Incidence, risk factors, and consequences of residual neuromuscular block in the United States: The prospective, observational, multicenter RECITE-US study. J Clin Anesth 2018; 55: 33-41

90. Saasouh W, Laffey K, Turan A, Avitsian R, Zura A, You J, Zimmerman NM, Szarpak L, Sessler DI, Ruetzler K: Degree of obesity is not associated with more than one intubation attempt: a large centre experience. Br J Anaesth 2018; 120: 1110-6

91. Sari S, Kozanhan B, Egilmez AI, Soyder A, Aydin ON, Galimberti F, Sessler D, Turan A: [The influence of the menstrual cycle on acute and persistent pain after laparoscopic cholecystectomy]. Rev Bras Anestesiol 2018; 68: 231-7

92. Schacham YN, Cohen B, Bajracharya GR, Walters M, Zimmerman N, Mao G, Tanios MA, Sessler DI: Mild perioperative hypothermia and myocardial injury: A retrospective cohort analysis. Anesth Analg 2018; 127: 1335-41

93. Schulte PJ, Mascha EJ: Propensity score methods: Theory and practice for anesthesia research. Anesth Analg 2018; 127: 1074-84

94. Sessler DI: Decision support alerts: importance of validation (editorial). Anesthesiology 2018; 128: 241-3

95. Sessler DI, Khanna AK: Perioperative myocardial injury and the contribution of hypotension. Intensive Care Med 2018; 44: 811-22

96. Sessler DI, Meyhoff CS, Zimmerman NM, Mao G, Leslie K, Vasquez SM, Balaji P, Alvarez-Garcia J, Cavalcanti AB, Parlow JL, Rahate PV, Seeberger MD, Gossetti B, Walker SA, Premchand RK, Dahl RM, Duceppe E, Rodseth R, Botto F, Devereaux PJ: Period-dependent associations between hypotension during and for four days after noncardiac surgery and a composite of myocardial infarction and death: A substudy of the POISE-2 trial. Anesthesiology 2018; 128: 317-27

97. Sessler DI, Shafer S: Writing research reports. Anesth Analg 2018; 126: 330-7

98. Smereka J, Szarpak L, Ruetzler K, Schacham Y, Smereka A, Dabrowski M, Terpilowska M, Terpilowski L, Adam I: A multicenter survey on toxoplasmosis knowledge among pregnant women in Poland (the TOWER study). BMC Pregnancy Childbirth 2018; 18: 389

99. Sonny A, Alfirevic A, Sale S, Zimmerman NM, You J, Gillinov AM, Sessler DI, Duncan AE: Reduced left ventricular global longitudinal strain predicts prolonged hospitalization: A cohort analysis of patients having aortic valve replacement surgery. Anesth Analg 2018; 126: 1484-93

100. Sreedharan R, Abdelmalak B: Diabetes mellitus: Preoperative concerns and evaluation. Anesthesiology Clinics 2018; 36: 581-97

101. Suarez S, Burke TF, Yusufali T, Makin J, Sessler DI: The role of ketamine in addressing the anesthesia gap in low-resource settings (editorial). J Clin Anesth 2018; 49: 42-3

102. Szarpak L, Ladny JR, Dabrowski M, Ladny M, Smereka J, Ahuja S, Ruetzler K: Comparison of 4 pediatric intraosseous access devices: A randomized simulation study. Pediatr Emerg Care 2018

103. Szarpak L, Madziala A, Czekajlo M, Smereka J, Kaserer A, Dabrowski M, Madziala M, Yakubtsevich R, Ladny JR, Ruetzler K: Comparison of the UEScope videolaryngoscope with the Macintosh laryngoscope during simulated cardiopulmonary resuscitation: A randomized, cross-over, multi-center manikin study. Medicine (Baltimore) 2018; 97: e12085

104. Sztain JF, Khatibi B, Monahan AM, Said ET, Abramson WB, Gabriel RA, Finneran JJt, Bellars RH, Nguyen PL, Ball ST, Gonzales FB, Ahmed SS, Donohue MC, Padwal JA, Ilfeld BM: Proximal versus distal continuous adductor canal blocks: Does varying perineural catheter location influence analgesia? A randomized, subject-masked, controlled clinical trial. Anesth Analg 2018; 127: 240-6

105. Turan A, Koyuncu O, Egan C, You J, Ruetzler K, Sessler DI, Cywinski JB: Effect of various durations of smoking cessation on postoperative outcomes: A retrospective cohort analysis. Eur J Anaesthesiol 2018; 35: 256-65

106. Vallabhajosyula S, Jentzer JC, Kotecha AA, Murphree DH, Jr., Barreto EF, Khanna AK, Iyer VN: Development and performance of a novel vasopressor-driven mortality prediction model in septic shock. Ann Intensive Care 2018; 8: 112

107. Vetter TR, Mascha EJ: Unadjusted bivariate two-group comparisons: When simpler is better. Anesth Analg 2018; 126: 338-42

108. Vetter TR, Schober P, Mascha EJ: Diagnostic testing and decision-making: Beauty is not just in the eye of the beholder. Anesth Analg 2018; 127: 1085-91

109. Wakefield BJ, Sacha GL, Khanna AK: Vasodilatory shock in the ICU and the role of angiotensin II. Curr Opin Crit Care 2018; 24: 277-85

110. Ward DS, Williams MR, Berkenbosch JW, Bhatt M, Carlson D, Chappell P, Clark RM, Constant I, Conway A, Cravero J, Dahan A, Dexter F, Dionne R, Dworkin RH, Gan TJ, Gozal D, Green S, Irwin MG, Karan S, Kochman M, Lerman J, Lightdale JR, Litman RS, Mason KP, Miner J, O'Connor RE, Pandharipande P, Riker RR, Roback MG, Sessler DI, Sexton A, Tobin JR, Turk DC, Twersky RS, Urman RD, Weiss M, Wunsch H, Zhao-Wong A: Evaluating patient-centered outcomes in clinical trials of procedural sedation, part 2 safety: Sedation consortium on endpoints and procedures for treatment, education, and research recommendations. Anesth Analg 2018; 127: 1146-54

111. Xie N, Matigian N, Vithanage T, Gregory K, Nassar ZD, Cabot PJ, Shaw PN, Kirkpatrick CMJ, Cao K-AL, Sturgess D, Parat M-O: Effect of perioperative opioids on cancer-relevant circulating parameters: Mu opioid receptor and toll-like receptor 4 activation potential, and proteolytic profile. Clinical Cancer Research 2018; 24: 2319-27

112. Yilmaz HO, Babazade R, Leung S, Zimmerman NM, Makarova N, Saasouh W, Stocchi L, Gorgun E, Sessler DI, Turan A: Postoperative hypotension and surgical site infections after colorectal surgery: A retrospective cohort study. Anesth Analg 2018; 127: 1129-36

Full Papers in press

1. Turan A, Bajracharya G, Leung S, Yazici M, Guangmei M, Bodsford T, Ruetzler K, Maheshwari K, Sakr Esa WA, Elsharkkawy H, Sessler DI: Association of neuraxial anesthesia with postoperative venous thromboembolism after noncardiac surgery: a propensity-matched analysis of ACS-NSQIP database. Anesth Analg

2. Bomberg H, Meiser F, Daume P, Bellgardt M, Volk T, Sessler DI, Groesdonk HV, Meiser A: Halving the volume of AnaConDa: Evaluation of a new small-volume anesthetic reflector in a test lung model. Anesth Analg

3. Koch CG, Duncan AI, Figueroa P, Dai L, Sessler DI, Frank SM, Ness PM, Mihaljevic T, Blackstone EH: Real age: red blood cell aging during storage. Ann Thorc Surg

4. Hüppe T, Klasen R, Maurer F, Meiser A, Groesdonk H, Sessler DI, Fink T, Kreuer: Volatile organic compounds in patients with renal failure, and changes during dialysis. Crit Care Med

5. Royse C, Canty D, Sessler DI: Perioperative ultrasound-assisted clinical evaluation — a case based review. Austrialasian J Ultrasound Med

6. Farag E, Makarova N, Argalious M, Cywinski JB, Benzel E, Kalfas I, Sessler DI: Vasopressor infusion during prone spine surgery and acute renal injury: a retrospective cohort Analysis. Anesth analg

7. Cohen B, Ahuhja S, Schacham YN, Chelnick D, Mao G, Sessler DI, Turan A: Intraoperative hyperoxia does not reduce post-operative pain: sub-analysis of an alternating cohort trial. Anesth Analg

8. Cohen B, Glosser L, Chelnick D, Hanline C, Raza Y, Walters M, Leung S, Essber H, Khoshknabi D, Saab, R, Zhang K, Tanios M, Ahmed M, Zafeer M, Mejie M, Rivas-Ferreira E, Bajracharia G, Yang D, Liu L, Ma C, Sessler DI, Turan A: Safety of bupivacaine liposome injectable suspension (Exparel) for postsurgical pain in pediatric surgical patients: a retrospective cohort analysis. Ped Anesth

9. Kabon B, Sessler DI, Kurz A, Crystalloid-Colloid Study Team: Effect of intraoperative goal-directed balanced crystaloid versus colloid administration on major postoperative morbidity: a randomized trial. Anesthesiology

10. Turan A, Chang C, Cohen B, Saasouh W, Essber H, Yang D, Ma C, Hovsepyan K, Khanna AK, Vitale J, Shah A, Ruetzler K, Maheshwari K, Sessler DI: The incidence, severity, and detection of blood pressure perturbations after abdominal surgery: a prospective blinded observational study. Anesthesiology

11. Turan A, Cohen B, Whitlock RP, Essber H, Niazi A, Makarova N, Saasouh W, Alfirevic A, Marciniak D, Sessler DI: Methlprednisolone does not reduce acute postoperative pain after cardiac surgery — sub-analysis of a randomized clinical trial Anesth Analg

12. Elsharkawy H, Barnes T, Babazede R, Huarte M, Wael Ali Sakr Esa, Ilfeld BM. Preliminary experience with epidural and perineural catheter localization with pulsed wave Doppler and M-Mode ultrasonography. Minerva Anestesiol

13. Ilfeld BM, Ball ST, Gabriel RA, Sztain JF, Monahan AM, Abramson WB, Khatibi B, Said ET, Parekh J, Grant SA, Wongsarnpigoon A, Boggs JW. A feasibility study of percutaneous peripheral nerve stimulation for the treatment of postoperative pain following total knee arthroplasty: A case series. Neuromodulation

14. Ilfeld BM, Said ET, Finneran JJ, Sztain JF, Abramson WB, Gabriel RA, Khatibi B, Swisher MW, Jaeger PT, Covey DC, Robertson CM. Ultrasound-guided percutaneous peripheral nerve stimulation: Neuromodulation of the femoral nerve for postoperative analgesia following ambulatory anterior cruciate ligament reconstruction, a proof of concept study. Neuromodulation

15. Sztain JF, Finneran JJ, Monahan AM, Khatibi B, Nguyen PL, Madison SJ, Bellars RH, Gabriel RA, Padwal JA, Ahmed SS, Schwartz AK, Kent WT, Donohue MC, Ilfeld BM. Traditional proximal supra-paraneural vs. distal sub-paraneural continuous popliteal-sciatic blocks for postoperative analgesia: A randomized, subject-masked, controlled clinical trial. Anesth Analg

16. Andersen JH, Geisler A, Estrup S, Vilhelmsen F, Jaeger P, Grevstad U, Dahl JB, Laier GH, Ilfeld BM, Mathiesen O. Systemic dexmedetomidine is not as efficient as perineural dexmedetomidine in pro-longing an ulnar nerve block: A randomized, triple-masked, controlled, non-inferiority trial in healthy volunteers. Reg Anesth Pain Med

17. Ilfeld BM, Finneran JJ, Gabriel RA, Said ET, Nguyen PL, Abramson WB, Khatibi B, Sztain JF, Swisher MW, Jaeger PT, Covey DC, Meunier MJ, Hentzen ER, Robertson CM. Ultrasound-guided percutaneous peripheral nerve stimulation: Neuromodulation of the suprascapular nerve and brachial plexus for postoperative analgesia following ambulatory rotator cuff repair, a proof of concept study. Reg Anesth Pain Med

18. Ilfeld BM, Ball ST, Cohen SP, Hanling SR, Fowler IM, Wongsarnpigoon A, Boggs JW. Percutaneous peripheral nerve stimulation to control postoperative pain, decrease opioid use, and accelerate functional recovery following orthopedic trauma. Military Health

19. Babazade R, Saasouh W, Naylor AJ, Makarova N, Udeh CI, Turan A, Udeh BL: The cost-effectiveness of epidural, patient-controlled intravenous opioid analgesia, or transversus abdominis plane infiltration with liposomal bupivacaine for postoperative pain management. J Clin Anesth

20. Argalious M, Trombetta C, Makarova N, Saasouh W, Rajan S: Simulation Versus Problem Based Learning for Cerebrospinal Drainage Catheter Insertion and Management: A Randomized Trial in a Large Academic Anesthesiology Residency Program. J Cardiothorac Vasc Anesth

21. Maheshwari K, Cywinski J, Mathur P, Cummings KC, 3rd, Avitsian R, Crone T, Liska D, Campion FX, Ruetzler K, Kurz A. Identify and monitor clinical variation using machine intelligence: a pilot in colorectal surgery. J Clin Monit Comput

22. Szarpak L, Smereka J, Ladny JR, Ruetzler K. The thumbs angle used in the novel infant chest compression technique (new two-thumb technique, nTTT) can influence the quality parameters of resuscitation. Med Intensiva

23. Abdelmalak BB, You J, Kurz A, Kot M, Bralliar T, Remzi FH, Sessler DI: The effects of dexamethasone, light anesthesia, and tight glucose control on postoperative fatigue and quality of life after major noncardiac surgery: A randomized trial. J Clin Anesth

Editorials

1. Duncan AE: GIK: The cure we have been waiting for? Anesth Analg 2018; 126: 1121-3

2. Khanna AK: Searching for better outcomes in septic shock trials. J Crit Care 2018; 47: 331-2

3. Mascha EJ: Identifying the best cut-point for a biomarker, or not. Anesth Analg 2018; 127: 820-2

4. Michard F, Sessler DI: Ward monitoring 3.0. Br J Anaesth 2018; 121: 999-1001

5. Michard F, Sessler DI, Saugel B: Non-invasive arterial pressure monitoring revisited. Intensive Care Med 2018; 44: 2213-5

6. Sessler DI: Decision support alerts: importance of validation. Anesthesiology 2018; 128: 241-3

7. Suarez S, Burke TF, Yusufali T, Makin J, Sessler DI: The role of ketamine in addressing the anesthesia gap in low-resource settings. J Clin Anesth 2018; 49: 42-3

Books

1. Farag E, Argalious M, Tetzlaff JE, Sharma D. Basic Sciences in Anesthesia. Springer. Switzerland, 2018

Book Chapters

1. Vallabhajosyula S, Jentzer JC, Khanna AK: Vasodilatory shock in the ICU: perils, pitfalls and therapeutic options. In Annual Update in Intensive Care and Emergency Medicine 2018. Springer International, 2018, pp 99-111.

2. T. Végh: Anesthesia para la cirugía esofágica Manuel Granell Gill ed. Anestesia y reanimación en cirugía torácic, Editorial Medical Panamerica, Madrid, Spain, 2018. pp. 262-272.

3. Végh T: Légzéstámogatás (Ventilatory support) in László-Szabó-Fülesdi: Újraélesztés (Reanimation) Medicina Kiadó, Budapest, 2018

4. Barnes TJ, Benson A,Khanna AK. Myasthenia gravis patient coming for ureteroscopy. In:Straker et al. (eds). Anesthesiology: A Problem-Based Learning Approach. Oxford University Press, 2018.

5. Khanna AK, Mathur P. Acute Cardiovascular Complications after Bariatric Surgery.In: Rogula TG, Schauer PR, Fouse T. (eds) Prevention And Management Of Complications In Bariatric Surgery.Oxford University Press, 2018

6. Ruetzler K, Kurz A: Physiology of Temperature Control, Basic Sciences in Anesthesia, Springer, Cham, 2018, pp 365-372

7. Ruetzler K, Kurz A: Consequences of perioperative hypothermia. Handb Clin Neurol 2018; 157: 687-695

8. Sheerer C, Ruetzler K: Atrial Fibrillation. In (Ed.), Anesthesiology: A Problem-Based Learning Approach. Oxford, UK: Oxford University Press,. Retrieved 18 Jan. 2019